Evaluation of serum fibrinogen, plasminogen, α2-anti-plasmin, and plasminogen activator inhibitor levels (PAI) and their correlation with presence of retinopathy in patients with type 1 DM
| العنوان: | Evaluation of serum fibrinogen, plasminogen, α2-anti-plasmin, and plasminogen activator inhibitor levels (PAI) and their correlation with presence of retinopathy in patients with type 1 DM |
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| المؤلفون: | Reyhan Ersoy, Huseyin Simavli, Bekir Cakir, Fatma Yülek, Nagihan Ugurlu, Sefika Burcak Polat, Ozcan Erel |
| المصدر: | Journal of Diabetes Research Journal of Diabetes Research, Vol 2014 (2014) |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Article Subject, Adolescent, Turkey, Plasmin, Endocrinology, Diabetes and Metabolism, Fibrinogen, lcsh:Diseases of the endocrine glands. Clinical endocrinology, chemistry.chemical_compound, Young Adult, Endocrinology, Internal medicine, Diabetes mellitus, Plasminogen Activator Inhibitor 1, Prevalence, Medicine, Humans, Glycated Hemoglobin, Type 1 diabetes, alpha-2-Antiplasmin, lcsh:RC648-665, Diabetic Retinopathy, Neovascularization, Pathologic, business.industry, Reproducibility of Results, Retinal Vessels, Plasminogen, Diabetic retinopathy, Middle Aged, medicine.disease, Fibrosis, Diabetes Mellitus, Type 1, chemistry, Plasminogen activator inhibitor-1, Hyperglycemia, Female, business, Plasminogen activator, Biomarkers, medicine.drug, Retinopathy, Research Article |
| الوصف: | Background.Diabetic retinopathy (DR) is the leading cause of blindness in the world. Retinopathy can still progress despite optimal metabolic control. The aim of the study was to determine whether different degrees of DR (proliferative or nonproliferative) were associated with abnormally modulated hemostatic parameters in patients with T1DM.Method.52 T1DM patients and 40 healthy controls were enrolled in the study. Patients were subdivided into three categories. Group I was defined as those without retinopathy, group II with NPRP, and group III with PRP. We compared these subgroups with each other and the control group (Group IV) according to the serum fibrinogen, plasminogen, alpha2-anti-plasmin (α2-anti-plasmin), and PAI.Results. We detected that PAI-1, serum fibrinogen, and plasminogen levels were similar between the diabetic and control groups (P=0.209,P=0.224, andP=0.244, resp.), whereasα2-anti-plasmin was higher in Groups I, II, and III compared to the control group (P<0.01,P<0.05, andP<0.001, resp.). There was a positive correlation between serumα2-anti-plasmin and HbA1c levels (r=0,268,P=0.031).Conclusion. To our knowledge there is scarce data in the literature aboutα2-anti-plasmin levels in type 1 diabetes. A positive correlation betweenα2-anti-plasmin with HbA1c suggests that fibrinolytic markers may improve with disease regulation and better glycemic control. |
| وصف الملف: | text/xhtml |
| تدمد: | 2314-6753 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13712295d86e3fadebfc0fd38d2d322dTest https://pubmed.ncbi.nlm.nih.gov/24818165Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....13712295d86e3fadebfc0fd38d2d322d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23146753 |
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