المؤلفون: Xiuting Huang, Yumin Ma, Simin Zhang, Xiuying Zhang, Xueying Gao, Siqian Gong, Fang Zhang, Yingying Luo, Xiaoling Cai, Ling Chen, Qian Ren, Xueyao Han, Meng Li, Rui Zhang, Lingli Zhou, Yanai Wang, Wei Liu, Linong Ji, Xianghai Zhou, Yu Zhu

المصدر: Journal of Diabetes Research, Vol 2018 (2018)
Journal of Diabetes Research

مصطلحات موضوعية: Adult, Genetic Markers, Male, 0301 basic medicine, China, endocrine system, medicine.medical_specialty, Adolescent, Article Subject, Endocrinology, Diabetes and Metabolism, Type 2 diabetes, DNA, Mitochondrial, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Gastroenterology, Young Adult, 03 medical and health sciences, Endocrinology, Risk Factors, Internal medicine, Diabetes mellitus, Glucokinase, medicine, Humans, Genetic Predisposition to Disease, Liver neoplasm, Circulating MicroRNA, Hepatocyte Nuclear Factor 1-alpha, Aged, Type 1 diabetes, lcsh:RC648-665, business.industry, Case-control study, Area under the curve, Genetic Variation, Middle Aged, medicine.disease, HNF1A, MicroRNAs, Diabetes Mellitus, Type 1, Phenotype, 030104 developmental biology, Diabetes Mellitus, Type 2, Case-Control Studies, Mutation, Female, business, Research Article

الوصف: miR-122, the expression of which is regulated by several transcription factors, such as HNF1A, was recently reported to be associated with type 2 diabetes (T2DM) and hepatocellular carcinoma. HNF1A variants can cause diabetes and might be involved in the development of primary liver neoplasm. Differences in miR-122 expression among different types of diabetes have not been studied. This study aimed to investigate differences in serum miR-122 levels in Chinese patients with different forms of diabetes, including T2DM, type 1 diabetes (T1DM), HNF1A variant-induced diabetes (HNF1A-DM), glucokinase variant-induced diabetes (GCK-DM), and mitochondrial A3243G mutation-induced diabetes (MDM). In total, 12 HNF1A-DM patients, 24 gender-, age-, and body mass index-matched (1 : 2) T2DM patients and 24 healthy subjects were included in this study. In addition, 30 monogenic diabetes (11 GCK-DM and 19 MDM) and 17 T1DM patients were included. Fasted blood biochemistry and miR-122 were measured. The results showed that the HNF1A-DM patients had lower miR-122 levels [0.046 (0.023, 0.121)] than T2DM patients [0.165 (0.036, 0.939), P=0.02] and healthy controls [0.249 (0.049, 1.234), P=0.019]. The area under the curve of the receiver operating characteristic curve for miR-122 to discriminate HNF1A-DM and T2DM was 0.687 (95% CI: 0.52–0.86, P=0.07). There was no difference in serum miR-122 among HNF1A-DM, GCK-DM, MDM, and T1DM patients. Lower serum miR-122 is a unique feature of HNF1A-DM patients and might partially explain the increased risk for liver neoplasm and abnormal lipid metabolism in HNF1A-DM patients.

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الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f557dc31cb48531757016c89d1c1c9fTest
https://doi.org/10.1155/2018/7842064Test

المؤلفون: Shuru Chen, Kun Lin, Qiong Zeng, Yixi Wu, Xiaoping Yang

المصدر: Journal of Diabetes Research
Journal of Diabetes Research, Vol 2021 (2021)

مصطلحات موضوعية: Adult, Male, β cell function, medicine.medical_specialty, Time Factors, Adolescent, Article Subject, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, Residual, Diseases of the endocrine glands. Clinical endocrinology, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Endocrinology, Internal medicine, Insulin-Secreting Cells, Insulin Secretion, Medicine, Humans, In patient, Stage (cooking), Age of Onset, Child, Proportional Hazards Models, Glycated Hemoglobin, Type 1 diabetes, Receiver operating characteristic, C-Peptide, Proportional hazards model, business.industry, RC648-665, medicine.disease, Natural history, Diabetes Mellitus, Type 1, Disease Progression, Female, business, Corrigendum, Research Article, Follow-Up Studies

الوصف: Objective. To investigate the natural history and related factors of the pancreatic β-cell function in Chinese type 1 diabetic patients from 3C study Shantou center. Method. Stimulated C-peptide levels from follow-up data of 201 individuals in 3C study Shantou subgroup starting in 2012 were used. Residual β-cell function was defined as stimulated C − peptide level ≥ 0.2 pmol / mL , on the basis of cut-points derived from the Diabetes Control and Complications Trial (DCCT). Results. 36.8% of patients had residual β-cell function, and the percentage was 68.2% in newly diagnosed diabetic patients. COX regression analysis indicated that the age of diagnosis, HbA1C level, and duration were independent factors of residual β-cell function in individuals with ≤5 years duration, but in those with duration ≥5 years, only the age of diagnosis was a predictor. The pancreatic β-cell function mainly declined in the first 5 years of the duration, and the rate of decline was correlated negatively with the duration and age of diagnosis. Receiver operating characteristic (ROC) analysis indicated that the cut-off point of stimulated C-peptide was 0.615 pmol/mL in patients with

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الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3540e137a1063d5497ad1043f401c4a3Test

المؤلفون: Ping Ling, Sihui Luo, Yongwen Zhou, Hua Liang, Jianping Weng, Daizhi Yang, Liling Qiu, Xueying Zheng, Jinhua Yan, Wen Xu, Bin Yao

المصدر: Journal of Diabetes Research
Journal of Diabetes Research, Vol 2020 (2020)

مصطلحات موضوعية: Adult, Blood Glucose, Male, medicine.medical_specialty, Adolescent, One year follow up, Article Subject, Endocrinology, Diabetes and Metabolism, Fulminant, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, Gastroenterology, Diseases of the endocrine glands. Clinical endocrinology, Diabetic Ketoacidosis, Diagnosis, Differential, Translational Research, Biomedical, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Diabetes mellitus, Internal medicine, medicine, Humans, Young adult, Child, Type 1 diabetes, business.industry, RC648-665, medicine.disease, Ketoacidosis, Diabetes Mellitus, Type 1, Metabolic control analysis, Propensity score matching, Disease Progression, Female, Symptom Assessment, business, Research Article

الوصف: Background. Fulminant type l diabetes mellitus (FT1DM) is a subtype of type 1 diabetes mellitus (T1DM) with abrupt onset, but data on its progression was limited. This study was aimed at exploring the clinical features through one-year follow-up. Methods and Materials. Patients with T1DM finishing at least one-year follow-up from June 2011 to July 2018 were enrolled from Guangdong Type 1 Diabetes Translational Medicine Study. Patients who fulfilled the respective criteria were categorized as an FT1DM group and a typical T1DM group (TT1DM). The 1 : 4 propensity score matching based on onset age, duration, and gender was performed between the FT1DM and TT1DM groups. Characteristics at the onset and after one-year follow-up were compared between the two groups. Results. A total of 53 patients with FT1DM and 212 matched patients with TT1DM were included. At the onset, there was a shorter duration of symptomatic period before diagnosis observed in the FT1DM group than in the TT1DM group (2 [1, 7] vs. 30 [10, 60] days, P<0.001). FT1DM patients had higher plasma glucose levels and higher percentage of diabetes ketoacidosis (P<0.001, respectively). Both fasting and postprandial C-peptide levels (FCP and PCP, respectively) in FT1DM were significantly lower (P<0.001). At enrollment, the duration of diabetes was 0.03 (0.00, 0.81) and 0.07 (0.00, 1.11) years and the level of HbA1c was 7.21±1.56% and 10.06±3.23% (P<0.001) in the FT1DM and TT1DM groups, respectively. After one year, both FCP and PCP were still significantly lower in the FT1DM group (P<0.001, 0.022) and the HbA1c level was similar between the two groups (P=0.128). The level of HDL-C in FT1DM was significantly higher than that in the TT1DM group at enrollment (P=0.019), and the change from enrollment was significantly greater than that in the FT1DM group (P=0.042). Conclusion. Patients with FT1DM had more severe metabolic derangement and deficiency of insulin secretion than patients with TT1DM at the onset, but glycaemic and metabolic control was not worse than that in TT1DM.

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الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e2a8768d7c9e0f8e0936337259a8216Test

المؤلفون: Svein Solheim, Martin Heier, Vibeke Bratseth, Gemma Chiva-Blanch, Knut Dahl-Jørgensen, Hanna Dis Margeirsdottir, Ingebjørg Seljeflot, Harald Arnesen

المصدر: Journal of Diabetes Research, Vol 2020 (2020)
Journal of Diabetes Research

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, medicine.medical_specialty, Adolescent, Article Subject, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, CD34, 030204 cardiovascular system & hematology, Diseases of the endocrine glands. Clinical endocrinology, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Cell-Derived Microparticles, Annexin, Internal medicine, medicine, Humans, Hypoglycemic Agents, Insulin, Prospective Studies, Annexin A5, Child, Prospective cohort study, Glycemic, Type 1 diabetes, business.industry, medicine.disease, RC648-665, Diabetes Mellitus, Type 1, 030104 developmental biology, Apoptosis, Cohort, Female, business, Biomarkers, Research Article

الوصف: Background. Type 1 diabetes is a chronic disease including hyperglycemia and accelerated atherosclerosis, with high risk of micro- and macrovascular complications. Circulating microvesicles (cMVs) are procoagulant cell fragments shed during activation/apoptosis and discussed to be markers of vascular dysfunction and hypercoagulability. Limited knowledge exists on hypercoagulability in young diabetics. We aimed to investigate cMVs over a five-year period in children/adolescents with type 1 diabetes compared with controls and any associations with glycemic control and cardiovascular risk factors. We hypothesized increased shedding of cMVs in type 1 diabetes in response to vascular activation. Methods. The cohort included type 1 diabetics (n=40) and healthy controls (n=40), mean age 14 years (range 11) at inclusion, randomly selected from the Norwegian Atherosclerosis and Childhood Diabetes (ACD) study. Citrated plasma was prepared and stored at -80°C until cMV analysis by flow cytometry. Results. Comparable levels of Annexin V (AV+) cMVs were observed at inclusion. At five-year follow-up, total AV+ cMVs were significantly lower in subjects with type 1 diabetes compared with controls; however, no significant differences were observed after adjusting for covariates. In the type 1 diabetes group, the total AV+, tissue factor-expressing AV+/CD142+, neutrophil-derived AV+/CD15+ and AV+/CD45+/CD15+, and endothelial-derived AV+/CD309+ and CD309+/CD34+ cMVs were inversely correlated with HbA1c (r=‐0.437, r=‐0.515, r=‐0.575, r=‐0.529, r=‐0.416, and r=‐0.445, respectively; all p≤0.01), however, only at inclusion. No significant correlations with cardiovascular risk factors were observed. Conclusions. Children/adolescents with type 1 diabetes show similar levels of AV+ cMVs as healthy controls and limited associations with glucose control. This indicates that our young diabetics on intensive insulin treatment have preserved vascular homeostasis and absence of procoagulant cMVs.

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الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c0a76fa8f63d80fd3027a570ffd6016Test
https://doaj.org/article/bc73eb837e354f188eed3e2274a71899Test

المؤلفون: Aila J. Ahola, Valma Harjutsalo, Carol Forsblom, Per-Henrik Groop

المساهمون: HUS Abdominal Center, Department of Medicine, Nefrologian yksikkö, University of Helsinki, Helsinki University Hospital Area, CAMM - Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, Research Programs Unit, Per Henrik Groop / Principal Investigator

المصدر: Journal of Diabetes Research
Journal of Diabetes Research, Vol 2020 (2020)

مصطلحات موضوعية: Adult, Blood Glucose, Male, Stress management, medicine.medical_specialty, CHOICES, Article Subject, Endocrinology, Diabetes and Metabolism, Perceived Stress Scale, 030209 endocrinology & metabolism, Overweight, Diseases of the endocrine glands. Clinical endocrinology, Body Mass Index, 03 medical and health sciences, TIME PHYSICAL-ACTIVITY, 0302 clinical medicine, Endocrinology, FOOD, Internal medicine, Diabetes mellitus, Medicine, QUALITY, Humans, 030212 general & internal medicine, 2. Zero hunger, Type 1 diabetes, OVERWEIGHT, business.industry, Feeding Behavior, Middle Aged, medicine.disease, RC648-665, Obesity, Diet, Diabetes Mellitus, Type 1, Quartile, OBESITY, 3121 General medicine, internal medicine and other clinical medicine, Patient Compliance, UNIVERSITY, Female, medicine.symptom, business, Body mass index, Stress, Psychological, Research Article

الوصف: Stress may negatively impact self-management of diabetes and thereby deteriorate glycaemic control. Eating is the most frequently reported stress-release method. In this study, we investigated the association between perceived stress (PS), dietary adherence, and glycaemic control. Data from participants in the FinnDiane Study with type 1 diabetes who had completed a diet questionnaire and Cohen’s perceived stress scale (PSS) were included. In addition to using a continuous PSS score, participants were divided into three groups based on the PSS scores: the first PSS quartile, low levels of PS; second and third quartiles, moderate levels of PS; and fourth quartile, high levels of PS. A diet score reflecting the level of adherence to dietary recommendations was calculated. Analyses were conducted in the whole sample and in subgroups divided by body mass index (BMI<25 kg/m2 vs. BMI≥25 kg/m2). In the whole sample, high PS and continuous stress score were negatively associated with the diet score and with adherence to fish, fresh vegetable, low-fat liquid milk product, and vegetable oil-based cooking fat recommendations. The stress score was negatively associated with the diet score both in lean and in those overweight or obese. However, fish and fresh vegetable recommendations were only affected in those with corpulence. PS was not associated with mean blood glucose concentrations in the whole sample. When divided by BMI status, worse glycaemic control was observed in lean subjects reporting stress. In individuals with overweight or obesity, instead, high glucose concentrations were observed regardless of the level of perceived stress. Interventions to improve stress management could improve dietary adherence and glycaemic control and could thereby have the potential to improve long-term health and well-being of individuals with type 1 diabetes.

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الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::029530432c70116ada292c60bb056477Test

المؤلفون: Sara K. Bartz, Khalid Sheikh, Sarah K. Lyons, Daniel J. DeSalvo

المصدر: Journal of Diabetes Research, Vol 2018 (2018)
Journal of Diabetes Research

مصطلحات موضوعية: Adult, Blood Glucose, Male, Insulin pump, Gerontology, Time Factors, Adolescent, Article Subject, endocrine system diseases, Cross-sectional study, Endocrinology, Diabetes and Metabolism, Ethnic group, 030209 endocrinology & metabolism, Single Center, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Young Adult, 03 medical and health sciences, Insulin Infusion Systems, 0302 clinical medicine, Endocrinology, Predictive Value of Tests, Diabetes mellitus, Humans, Hypoglycemic Agents, Insulin, Medicine, 030212 general & internal medicine, Young adult, Child, Glycemic, Glycated Hemoglobin, Type 1 diabetes, lcsh:RC648-665, business.industry, Blood Glucose Self-Monitoring, Age Factors, nutritional and metabolic diseases, medicine.disease, Texas, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Treatment Outcome, Child, Preschool, Female, business, Biomarkers, Research Article

الوصف: Aim. The purpose of this cross-sectional study was to determine the rates of diabetes device use (insulin pump and continuous glucose monitor (CGM)) and association with glycemic control in youth with type 1 diabetes in a large, diverse pediatric center. Methods. Demographic and clinical data were obtained from 1992 patients who met the eligibility criteria (age Results. Mean age was 13.8 ± 4.2 years, 50.7% were female, diabetes duration was 6.2 ± 4 years, and mean HbA1c was 8.7 ± 1.8%. Overall, 38.2% of patients were on pump therapy and 18.5% were on CGM. Patients who were non-Hispanic (NH) white, privately insured, and with primary English-speaking parent(s) had higher rates of insulin pump use, as well as CGM use (P<0.001 for both). Female patients had higher rates of pump use only (P<0.01). Private health insurance, NH white race/ethnicity, and CGM use were each associated with lower HbA1c (P=0.03, Conclusion. At a large, diverse, pediatric diabetes center, disparities in diabetes device use were present across sex, race/ethnicity, health insurance coverage, and primary language of parent(s). CGM use was associated with lower HbA1c. Quality improvement efforts are underway to ensure improved access, education, and clinical programs for advanced diabetes devices for T1D patients.

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الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16071bd7d9e65f25b3b78ea6b648b389Test
https://doi.org/10.1155/2018/5162162Test

المؤلفون: Shizuka Nakamura, Hidetada Ogata, Takahiro Ito, Hiromi Takashima, Masahito Katahira, Tsutomu Miwata, Megumi Goto

المصدر: Journal of Diabetes Research
Journal of Diabetes Research, Vol 2018 (2018)

مصطلحات موضوعية: Adult, Male, Risk, endocrine system, medicine.medical_specialty, Article Subject, Endocrinology, Diabetes and Metabolism, Radioimmunoassay, Enzyme-Linked Immunosorbent Assay, 030209 endocrinology & metabolism, Type 2 diabetes, 030204 cardiovascular system & hematology, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Gastroenterology, Autoimmune Diseases, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Insulin-Secreting Cells, Internal medicine, Diabetes mellitus, medicine, Humans, Insulin, Aged, Autoantibodies, Type 1 diabetes, lcsh:RC648-665, biology, business.industry, Insulin deficiency, Middle Aged, medicine.disease, Thyroid Diseases, Titer, Diabetes Mellitus, Type 1, Concomitant, Disease Progression, biology.protein, Female, Antibody, business, hormones, hormone substitutes, and hormone antagonists, Research Article

الوصف: The presence of antiglutamic acid decarboxylase antibody (GADA) is required for the diagnosis of slowly progressive type 1 diabetes (SPT1D). We examined the factors influencing GADA determination by radioimmunoassay (GADA-RIA) and by enzyme-linked immunosorbent assay (GADA-ELISA). Sixty patients with SPT1D and 154 patients with type 2 diabetes were examined by both GADA-RIA and GADA-ELISA and for the presence of autoimmune thyroid disease (AITD). We compared the clinical characteristics of these patients based on the positivity or negativity of GADA-RIA and GADA-ELISA, and the existence or nonexistence of AITD. Thirty of 60 (50.0%) GADA-RIA-positive patients were GADA-ELISA negative, whereas none of the 154 GADA-RIA-negative patients were GADA-ELISA positive. Concomitant AITD was significantly less in patients with GADA-RIA and without GADA-ELISA and was significantly more in patients with GADA-RIA and GADA-ELISA. In GADA-RIA-positive patients, there was no significant difference in the GADA-RIA titer among the GADA-ELISA-negative patients with and without AITD, and the GADA-ELISA-positive patients without AITD; whereas the frequency of insulin deficiency was significantly higher in the patients with AITD and/or GADA-ELISA than in those without AITD and GADA-ELISA. Examination of GADA-ELISA and AITD in GADA-RIA-positive patients might be useful in predicting insulin deficiency in these patients.

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الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f55e447a85381c6c838eb9e8ef358d09Test
https://doi.org/10.1155/2018/1847430Test

المؤلفون: Hisham A. Zaghloul, Irfan Altaf Ansari, Mohi Iqbal Mohammad Abdul, Syed Azhar Syed Sulaiman, Syed Wasif Gillani, Hassaan Anwar Rathore, Mirza R. Baig

المصدر: Journal of Diabetes Research
Journal of Diabetes Research, Vol 2018 (2018)

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Article Subject, Cross-sectional study, Health Status, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Disease, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Young Adult, 03 medical and health sciences, Social support, Sex Factors, 0302 clinical medicine, Endocrinology, Surveys and Questionnaires, Internal medicine, Diabetes mellitus, medicine, Humans, 030212 general & internal medicine, Glycemic, Type 1 diabetes, lcsh:RC648-665, business.industry, Social Support, Middle Aged, medicine.disease, Distress, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Mental Health, Quality of Life, Female, business, Psychosocial, Research Article

الوصف: Background. This study is aimed at investigating the various disease-specific and health-related psychosocial concepts of HRQOL among insulin-dependent diabetes mellitus (IDDM) and understanding the gender differences in HRQOL among IDDM patients. Methods. A cross-sectional observational study was conducted to assess the effect of health-related and psychosocial correlates on HRQOL of IDDM patients in Penang, Malaysia. The participants were recruited from five governmental diabetic clinics. Patients with insulin use only, IDDM diagnosed at least 1 year earlier, were identified from clinical registers. The sample was then age stratified for 20–64 years, and severe complications (e.g., end-stage renal failure, hemodialysis, and liver cirrhosis) were excluded; a total of 1003 participants were enrolled in the study. Multivariate regression analysis was used to predict the response. Results. A total of 853 (100%) participants were enrolled and completed the study. Women exhibited significantly higher/better mental health (p<0.013) and health perception scores (p<0.001) despite high prevalence of impaired role (49.2%), social (24.2%), and physical (40.5%) functionings as compared to men. Women with longer diabetes exposure and uncontrolled glycemic levels (HbA1c) have poorer HRQOL. Availability of social support showed no significant association with either HRQOL or diabetes distress levels. Diabetes distress levels remained not associated with social support. Women also showed significantly higher association with health perception (15% versus 13% men, p<0.001) and mental health (13% versus 11% men, p<0.001) in diabetes-specific psychosocial factors. Thus, among women alone, diabetes-related specific and psychosocial factors explained 15% and 13% of variations in HRQOL extents, respectively. Conclusion. Women exhibit extensive and significant patterns with health-related factors and diabetes-specific psychosocial factors (self-efficacy, social support, and DLC) to improve HRQOL. Also, women have significantly high reported distress levels and low social functioning compared to men.

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الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99aa25b3213544a9c504cbe1b76226edTest
https://doi.org/10.1155/2018/4079087Test

المؤلفون: George P. Chrousos, Ioannis Papassotiriou, Jeanette Wahlberg, Alexandra Margeli, Nektaria Papadopoulou-Marketou, Christina Kanaka-Gantenbein

المصدر: Journal of Diabetes Research, Vol 2017 (2017)
Journal of Diabetes Research

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Adolescent, Heart Diseases, Article Subject, Systole, Endocrinology, Diabetes and Metabolism, Renal function, 030209 endocrinology & metabolism, Endocrinology and Diabetes, 030204 cardiovascular system & hematology, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Prehypertension, Diabetic nephropathy, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Lipocalin-2, Internal medicine, Diabetes mellitus, medicine, Albuminuria, Humans, Diabetic Nephropathies, Prospective Studies, Young adult, Child, Prospective cohort study, Type 1 diabetes, lcsh:RC648-665, Predictive marker, business.industry, medicine.disease, Diabetes Mellitus, Type 1, Child, Preschool, Hypertension, Endokrinologi och diabetes, Female, Kidney Diseases, business, Biomarkers, Research Article

الوصف: Aims. Type 1 diabetes (T1D) is often associated with early microvascular complications. Previous studies demonstrated that increased systolic (SAP) and diastolic arterial blood pressures (DAP) are linked to microvascular morbidity in T1D. The aim of the study was to investigate the predictive role of neutrophil gelatinase-associated lipocalin (NGAL) in unravelling early cardio-renal dysfunction in T1D. Methods. Two T1D patient groups participating in two-centre prospective cohorts were studied. Group A consisted of 57 participants aged 13.9 years (SD: 3.1) and group B consisted of 59 patients aged 28.0 years (SD: 4.4). Forty-nine healthy children [age: 10.5 years (SD: 6.6)] and 18 healthy adults [age 27.7 years (SD: 4.2)] served as controls. Serum concentrations of NGAL (ELISA) were determined, and SAP and DAP were examined (SAP and DAP also expressed as z-scores in the younger group). Results. NGAL correlated positively with SAP in both patient groups (P=0.020 and P=0.031, resp.) and SAP z-score (P=0.009) (group A) and negatively with eGFR in both groups (P<0.001 and P<0.001, resp.). Conclusions. NGAL may be proposed as a biomarker of early renal dysfunction even in nonalbuminuric T1D patients, since it was strongly associated with renal function decline and increasing systolic arterial pressure even at prehypertensive range in people with T1D, in a broad age range.

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الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b700e14274541bb18870615d6b857507Test
https://doi.org/10.1155/2017/7526919Test

المؤلفون: Graham D. Ogle, Gabriel Andrew Gregory, Angela C Middlehurst, Elizabeth Duarte Gomez, Miriam Castrati Nostas, Alicia J. Jenkins

المصدر: Journal of Diabetes Research
Journal of Diabetes Research, Vol 2017 (2017)

مصطلحات موضوعية: Adult, Male, Bolivia, Pediatrics, medicine.medical_specialty, Adolescent, Article Subject, Diabetic Cardiomyopathies, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, 030209 endocrinology & metabolism, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Cohort Studies, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Cost of Illness, Risk Factors, Diabetes mellitus, medicine, Humans, 030212 general & internal medicine, Renal replacement therapy, Mortality, Young adult, Risk factor, Child, Glycemic, Type 1 diabetes, lcsh:RC648-665, business.industry, Incidence, Mortality rate, Incidence (epidemiology), Urban Health, Infant, medicine.disease, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Cardiovascular Diseases, Child, Preschool, Female, business, Diabetic Angiopathies, Follow-Up Studies, Research Article

الوصف: Objectives. To determine incidence, mortality, and clinical status of youth with diabetes at the Centro Vivir con Diabetes, Cochabamba, Bolivia, with support from International Diabetes Federation Life for a Child Program.Methods. Incidence/mortality data analysis of all cases (Results. Over 12.2 years, 144 cases with type 1 diabetes (T1D) were diagnosed; 43.1% were male. Diagnosis age was 0.3–22.2 y; peak was 11-12 y. 11.1% were Conclusions. Bolivia has low T1D incidence. Reasonable glycemic control is being achieved despite limited resources; however, some have serious complications and adverse cardiovascular risk factor profiles. Further attention is needed for complications.

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الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bfcad284166f4e1a8107352cc7bfa99Test
https://doi.org/10.1155/2017/8454757Test