Association between influenza and the incidence rate of new‐onset type 1 diabetes in Japan
| العنوان: | Association between influenza and the incidence rate of new‐onset type 1 diabetes in Japan |
|---|---|
| المؤلفون: | Sadanori Okada, Takehiro Sugiyama, Tomoaki Imamura, Tomoya Myojin, Hitoshi Ishii, Tsuneyuki Higashino, Tatsuya Noda, Shinichiro Kubo, Hiroki Nakajima, Yuichi Nishioka |
| المصدر: | Journal of Diabetes Investigation, Vol 12, Iss 10, Pp 1797-1804 (2021) Journal of Diabetes Investigation |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, Population, 030209 endocrinology & metabolism, Rate ratio, Diseases of the endocrine glands. Clinical endocrinology, Young Adult, 03 medical and health sciences, symbols.namesake, 0302 clinical medicine, Japan, Diabetes mellitus type 1, Internal medicine, Diabetes mellitus, Influenza, Human, Internal Medicine, medicine, Humans, Poisson regression, Child, education, Aged, Retrospective Studies, Type 1 diabetes, education.field_of_study, business.industry, Incidence, Infant, Retrospective cohort study, Original Articles, General Medicine, Middle Aged, medicine.disease, RC648-665, Confidence interval, Influenza, Diabetes Mellitus, Type 1, 030104 developmental biology, Child, Preschool, Cohort, symbols, Female, Original Article, business |
| الوصف: | Aim This study aimed to determine whether there is an association between influenza and new‐onset type 1 diabetes. Materials and methods This population‐based retrospective cohort study used data from the National Database of Health Insurance Claims and Specific Health Check‐ups of Japan. Influenza was defined based on drug prescriptions and the onset of type 1 diabetes was defined using specific medical codes indicating a diagnosis of type 1 diabetes. The incidence rate ratio of new‐onset type 1 diabetes within 180 days after an influenza diagnosis was calculated and it was compared with that at other times using Poisson regression and generalized estimating equations. Sensitivity analyses were performed to confirm the robustness of this finding. Results The data of 10,400 patients with new‐onset type 1 diabetes were analyzed, including 2,196 (952 male 1,244 female) patients diagnosed with influenza between 1 September 2014 and 31 August 2017. Although only patients with type 1 diabetes were included, adjusted analysis showed that individuals had a 1.3‐fold (95% confidence interval: 1.15–1.46) higher risk of developing type 1 diabetes in the first 180 days after influenza diagnosis than that at other times. Conclusions In this Japanese population‐based cohort, the risk of new‐onset type 1 diabetes may increase after the diagnosis of influenza. These results, which must be confirmed in other populations, suggest that influenza may be a causal factor for new‐onset type 1 diabetes. The molecular mechanisms underlying the potential etiological relationship between influenza and type 1 diabetes should be elucidated. In this Japanese population‐based cohort, the risk of new‐onset type 1 diabetes increased after being diagnosed with influenza. These results, which must be confirmed in other populations, suggest that influenza may be a causal factor for new‐onset type 1 diabetes. The molecular mechanisms underlying the potential etiological relationship between influenza and type 1 diabetes should be elucidated. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2040-1116 2040-1124 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2addc8fa0427d6b6ec3052b564d1117Test https://doaj.org/article/6e005e4f525042c88b95614b668a0c6dTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e2addc8fa0427d6b6ec3052b564d1117 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20401116 20401124 |
|---|