Neural effects of gut‐ and brain‐derived glucagon‐like peptide‐1 and its receptor agonist
| العنوان: | Neural effects of gut‐ and brain‐derived glucagon‐like peptide‐1 and its receptor agonist |
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| المؤلفون: | Kenichi Katsurada, Toshihiko Yada |
| المصدر: | Journal of Diabetes Investigation |
| بيانات النشر: | John Wiley and Sons Inc., 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Agonist, medicine.medical_specialty, endocrine system, medicine.drug_class, Proceedings of INCRETIN 2015, A Symposium Celebrating the 45th Anniversary of the Discovery of GIP, 29–31 July 2015, Vancouver, Canada. This publication has been supported by: The Local Organizing Committee of INCRETIN 2015, Endocrinology, Diabetes and Metabolism, Mini Review, Enteroendocrine Cells, Central nervous system, Incretin, Enteroendocrine cell, Biology, Cardiovascular, Brain stem, Glucagon-Like Peptide-1 Receptor, Cardiovascular Physiological Phenomena, 03 medical and health sciences, chemistry.chemical_compound, Mice, Glucagon-Like Peptide 1, Internal medicine, Internal Medicine, medicine, Solitary Nucleus, Animals, Humans, Neurotransmitter, Receptor, Review Articles, Solitary nucleus, Feeding, digestive, oral, and skin physiology, General Medicine, Feeding Behavior, Glucagon-like peptide-1, Rats, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, chemistry, hormones, hormone substitutes, and hormone antagonists |
| الوصف: | Glucagon‐like peptide‐1 (GLP‐1) is derived from both the enteroendocrine L cells and preproglucagon‐expressing neurons in the nucleus tractus solitarius (NTS) of the brain stem. As GLP‐1 is cleaved by dipeptidyl peptidase‐4 yielding a half‐life of less than 2 min, it is plausible that the gut‐derived GLP‐1, released postprandially, exerts its effects on the brain mainly by interacting with vagal afferent neurons located at the intestinal or hepatic portal area. GLP‐1 neurons in the NTS widely project in the central nervous system and act as a neurotransmitter. One of the physiological roles of brain‐derived GLP‐1 is restriction of feeding. GLP‐1 receptor agonists have recently been used to treat type 2 diabetic patients, and have been shown to exhibit pleiotropic effects beyond incretin action, which involve brain functions. GLP‐1 receptor agonist administered in the periphery is stable because of its resistance to dipeptidyl peptidase‐4, and is highly likely to act on the brain by passing through the blood–brain barrier (BBB), as well as interacting with vagal afferent nerves. Central actions of GLP‐1 have various roles including regulation of feeding, weight, glucose and lipid metabolism, cardiovascular functions, cognitive functions, and stress and emotional responses. In the present review, we focus on the source of GLP‐1 and the pathway by which peripheral GLP‐1 informs the brain, and then discuss recent findings on the central effects of GLP‐1 and GLP‐1 receptor agonists. |
| اللغة: | English |
| تدمد: | 2040-1124 2040-1116 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdddc2c0f0749b93528dfada6f8fc391Test http://europepmc.org/articles/PMC4854507Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fdddc2c0f0749b93528dfada6f8fc391 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20401124 20401116 |
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