التفاصيل البيبلوغرافية
| العنوان: |
Obesity, visceral adiposity and carotid atherosclerosis. |
| المؤلفون: |
Haberka, Maciej1 (AUTHOR) mhaberka@sum.edu.pl, Skilton, Michael1 (AUTHOR), Biedroń, Małgorzata1 (AUTHOR), Szóstak-Janiak, Karolina1 (AUTHOR), Partyka, Małgorzata1 (AUTHOR), Matla, Monika1 (AUTHOR), Gąsior, Zbigniew1 (AUTHOR) |
| المصدر: |
Journal of Diabetes & its Complications. Apr2019, Vol. 33 Issue 4, p302-306. 5p. |
| مستخلص: |
Carotid artery atherosclerosis is a complex and multifactorial chronic disease. Our aim was to assess the associations between obesity, fat depots and carotid artery stenosis (CAS) in patients with high cardiovascular (CV) risk.Methods: The study group included 391 patients (F/M: 136/255 pts.; age: 61.8 ± 8 years) scheduled for elective coronary angiography. A comprehensive clinical assessment included a carotid artery and abdominal ultrasound involving the following fat depots: (1) carotid extra-media thickness (EMT) indexed to the body mass index (perivascular adipose tissue [PVAT]), and (2) abdominal visceral and subcutaneous fat.Results: Patients with a ≥50% stenosis of internal carotid artery (ICA) were older (65.9 ± 7 vs 60.3 ± 7 years, p < 0.0001) and had increased PVAT (836 ± 120 vs 779 ± 127 μm, p < 0.01) compared to individuals with <50% internal carotid artery stenosis. None of the CAS parameters were associated with any measures of obesity. Multivariable regression model showed that age (p < 0.0001), PVAT (p < 0.0001) and smoking (p = 0.04) were independently associated with the severity of ICA stenosis.Conclusions: Our study showed that carotid extra-media thickness, an index measure of PVAT, is associated with CAS severity. It is a strong and independent predictor of significant ICA stenosis. None of the obesity measurements revealed associations with carotid atherosclerosis. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
