التفاصيل البيبلوغرافية
| العنوان: |
Antibody response against three widespread bovine viruses is not impaired in Holstein cattle carrying bovine leukocyte antigen DRB3.2 alleles associated with bovine leukemia virus resistance. |
| المؤلفون: |
Juliarena, M. A.1, Poli, M.2, Ceriani, C.3, Sala, L.2, Rodriguez, E.4, Gutierrez, S.3, Dolcini, G.3, Odeon, A.5, Esteban, E. N.1 esteban@vet.unicen.edu.ar |
| المصدر: |
Journal of Dairy Science. Jan2009, Vol. 92 Issue 1, p375-381. 7p. 3 Charts. |
| مصطلحات موضوعية: |
*IMMUNOGLOBULINS, *BOVINE leukemia virus, *HOLSTEIN-Friesian cattle, *DAIRY cattle, *ANTIGENS, *CATTLE genetics, *NATURAL immunity, *BIOMARKERS |
| مستخلص: |
Due to the wide dissemination of bovine leukemia virus (BLV) infection among dairy cattle, control and eradication programs based on serological detection of infected cattle and subsequent culling face a major economic task. In Argentina, genetic selection of cattle carrying alleles of the bovine leukocyte antigen (BoLA) DRB3.2 gene associated with BLV-infection resistance, like *0902, emerges as the best additional tool toward controlling virus spread. A potential risk in expanding or segregating BoLA selected populations of cattle is that it might increase susceptibility to other common viruses. Special concern raises the strong association found between low proviral load and low antibody titer against major BLV structural proteins. This phenomenon might depend on host genetic factors influencing other viruses requiring, unlike BLV, strong and long-lasting humoral immune response to prevent infection. In this study, we demonstrate that there is no association among neutralizing antibody titers against foot and mouth disease virus, bovine viral diarrhea virus, or bovine herpesvirus type 1 and polymorphism of the BoLA DRB3.2 gene. Conversely, there is strong association between BoLA DRB3.2*0902 and low antibody titers against 2 BLV structural proteins--env gp51 and gag p24--to date, the best BLV resistance marker. There is also significant association between low antibody titers against gp51 and p24 and BoLA DRB3.2*1701 and low antibody titers against p24 and BoLA DRB3.2*1101 or 02. Our data suggest that increasing BoLA-selected BLV-resistant cattle or segregating BoLA-associated alleles to BLV susceptibility would not affect the resistance or the predisposition to bovine viral diarrhea virus, bovine herpesvirus type 1, or foot and mouth disease virus infection. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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