التفاصيل البيبلوغرافية
| العنوان: |
Clinical characteristics of Pseudomonas and Aspergillus co-infected cystic fibrosis patients: A UK registry study. |
| المؤلفون: |
Hughes, Dominic A.1,2 (AUTHOR) d.hughes17@imperial.ac.uk, Archangelidi, Olga1 (AUTHOR), Coates, Matthew1 (AUTHOR), Armstrong-James, Darius2,3 (AUTHOR), Elborn, Stuart J.4 (AUTHOR), Carr, Siobhán B.1,2 (AUTHOR), Davies, Jane C.1,2 (AUTHOR) |
| المصدر: |
Journal of Cystic Fibrosis. Jan2022, Vol. 21 Issue 1, p129-135. 7p. |
| مصطلحات موضوعية: |
*CYSTIC fibrosis, *MEDICAL registries, *PSEUDOMONAS, *ASPERGILLUS, *ASPERGILLOSIS, *PULMONARY aspergillosis, *INFECTION |
| مصطلحات جغرافية: |
UNITED Kingdom |
| مستخلص: |
• Aspergillus airway infection was associated with a 5.9% lower adjusted ppFEV1. • Aspergillus was linked to poorer clinical outcomes in people with CF. • 9.1% of UK patients had evidence of Pseudomonas/Aspergillus coinfection in 2016. • Pseudomonas/Aspergillus coinfection was linked with increased IV antibiotic usage. • A prospective study is needed to explore the causation behind these associations. Pseudomonas aeruginosa (Pa) and Aspergillus species (Asp) are the most common bacterial and fungal organisms respectively in CF airways. Our aim was to examine impacts of Asp infection and Pa/Asp co-infection. Patients on the UK CF Registry in 2016 were grouped into: absent (Pa-), intermittent (Pai) or chronic Pa (Pac), each with Asp positive (Asp+) or negative (Asp-). Primary outcome was best percentage predicted FEV 1 (ppFEV 1) that year. Secondary outcomes were intravenous (IV) antibiotic courses, growth (height, weight, BMI) and additional disease complications. Associations between outcomes and infection-status were assessed using regression models adjusting for significant confounders (age, sex, Phe508del homozygosity and CF-related diabetes (CFRD)). 9,270 patients were included (median age 19 [IQR 9-30] years, 54% male, 50% Phe508del/F508del). 4,142 patients (45%) isolated Pa, 1,460 (16%) Asp. Pa-/Asp+ subjects had an adjusted ppFEV 1 that was 5.9% lower than Pa-/Asp- (p < 0.0001). In patients with Pai or Pac, there was no additional impact of Asp on ppFEV 1. However, there was a higher probability that Pac/Asp+ patients had required IV antibiotics than Pac/Asp- group (OR 1.23 [1.03-1.48]). Low BMI, ABPA, CF-liver disease and CFRD were all more frequent with Asp alone than Pa-/Asp-, though not more common in Pac/Asp+ than Pac/Asp-. Co-infection with Pa and Asp was not associated with reduced lung function compared with Pa alone, but was associated with additional use of IV antibiotics. Asp infection itself is associated with several important indicators of disease severity. Longitudinal analyses should explore the impact of co-infection on disease progression. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
Full Text Finder