Immunohistochemical features of cutaneous granulomas in primary immunodeficiency disorders: a comparison with cutaneous sarcoidosis
| العنوان: | Immunohistochemical features of cutaneous granulomas in primary immunodeficiency disorders: a comparison with cutaneous sarcoidosis |
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| المؤلفون: | Corry M.R. Weemaes, Willeke A. M. Blokx, Mieke Bergers, Marieke M B Seyger, Monique Link, Michelle E.A. de Jager, Adilia Warris |
| المصدر: | Journal of Cutaneous Pathology, 35, 5, pp. 467-72 Journal of Cutaneous Pathology, 35, 467-72 |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | CD4-Positive T-Lymphocytes, Male, Pathology, medicine.medical_specialty, Systemic disease, Histology, Sarcoidosis, Cutaneous Sarcoidosis, Dermatology, CD8-Positive T-Lymphocytes, Skin Diseases, Pathology and Forensic Medicine, Invasive mycoses and compromised host [N4i 2], Ataxia Telangiectasia, Translational research [ONCOL 3], Antigens, CD, T-Lymphocyte Subsets, hemic and lymphatic diseases, medicine, Cytotoxic T cell, Humans, Lymphocyte Count, Child, Immunodeficiency, Molecular diagnosis, prognosis and monitoring [UMCN 1.2], Chronic inflammation and autoimmunity [UMCN 4.2], Granuloma, business.industry, Immunologic Deficiency Syndromes, medicine.disease, Immunohistochemistry, Pathogenesis and modulation of inflammation [N4i 1], Autoimmune lymphoproliferative syndrome, Immunology, Primary immunodeficiency, Female, Microbial pathogenesis and host defense [UMCN 4.1], business, Biomarkers, Immunity, infection and tissue repair [NCMLS 1] |
| الوصف: | Contains fulltext : 69862.pdf (Publisher’s version ) (Closed access) BACKGROUND: Cutaneous granulomas can occur in patients with a primary immunodeficiency disorder. In some cases, an infectious cause cannot be revealed. The pathogenesis of these granulomas still remains to be elucidated. The aim of this study was to study differences or overlap between these rare granulomas and sarcoidosis-related granulomas. METHODS: Markers for T-cell subsets (CD3, CD4, CD8 and CD45RO), Langerhans' cells (CD1a), macrophages (CD68), B cells (CD20) and NK cells (CD56) were stained immunohistochemically. The amount of CD4+ and CD8+ cells in the granulomas was counted. Results were compared with the CD4+/CD8+ ratio in peripheral blood. RESULTS: In the granulomas of two of three patients with a primary immunodeficiency disorder, the cytotoxic T cells (CD8+) outnumbered the T-helper cells (CD4+) with a counted CD4+/CD8+ ratio <2. CONCLUSIONS: A lower CD4+/CD8+ ratio was found in the cutaneous granulomas of patients with a primary immunodeficiency disorder (unclassified combined immunodeficiency, autoimmune lymphoproliferative syndrome and ataxia teleangiectasia) as compared with the patients with cutaneous sarcoidosis. The possible implications of these findings are discussed in this paper. |
| وصف الملف: | application/pdf |
| تدمد: | 1600-0560 0303-6987 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e609464b1713922650bb0f8d7e7ce969Test https://pubmed.ncbi.nlm.nih.gov/18201241Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e609464b1713922650bb0f8d7e7ce969 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16000560 03036987 |
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