Association of Faecal Calprotectin Level and Combined Endoscopic and Radiological Healing in Patients With Crohn’s Disease Receiving Anti-tumour Necrosis Factor Therapy
| العنوان: | Association of Faecal Calprotectin Level and Combined Endoscopic and Radiological Healing in Patients With Crohn’s Disease Receiving Anti-tumour Necrosis Factor Therapy |
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| المؤلفون: | Jeong-Sik Byeon, Eun Hye Oh, Dong-Hoon Yang, Beyong Duk Ye, Seong Ho Park, Jeongseok Kim, Sang Hyoung Park, Jae Cheol Park, Jin Yong Kim, Soo Min Noh, Nam Seok Ham, Seung-Jae Myung, Sung Wook Hwang, Suk-Kyun Yang, Jung Bok Lee |
| المصدر: | Journal of Crohn's and Colitis. 14:1231-1240 |
| بيانات النشر: | Oxford University Press (OUP), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Serum albumin, Gastroenterology, Feces, Crohn Disease, Predictive Value of Tests, Recurrence, Internal medicine, Outcome Assessment, Health Care, Republic of Korea, medicine, Humans, Endoscopy, Digestive System, Serum Albumin, Crohn's disease, medicine.diagnostic_test, biology, business.industry, C-reactive protein, Adalimumab, General Medicine, medicine.disease, Faecal calprotectin, Infliximab, Confidence interval, Endoscopy, Radiography, Anti-Tumor Necrosis Factor Therapy, C-Reactive Protein, ROC Curve, biology.protein, Biomarker (medicine), Female, Tumor Necrosis Factor Inhibitors, business, Leukocyte L1 Antigen Complex, Biomarkers |
| الوصف: | Background and AimsCombined endoscopic and radiological healing, or deep healing, is associated with favourable outcomes in patients with Crohn’s disease; thus, a non-invasive biomarker for predicting deep healing would be invaluable. We evaluated the usefulness of faecal calprotectin for predicting deep healing in patients with Crohn’s disease receiving anti-tumour necrosis factor [TNF] therapy.MethodsWe analysed the records of patients with Crohn’s disease who received anti-tumour necrosis factor therapy and underwent endoscopic evaluation, radiological evaluation, and faecal calprotectin measurement within a period of 3 months between August 2017 and November 2018. Results of endoscopic and radiological studies were independently reviewed by two gastrointestinal endoscopists and a gastrointestinal radiologist, respectively. Serum C-reactive protein and albumin were also measured.ResultsOut of 268 patients analysed, 77 [28.7%] had deep healing, 36 [13.4%] had endoscopic healing only, 36 [13.4%] had radiological healing only, and 119 [44.4%] had neither. The median duration of anti-TNF treatment was 40.0 months. The deep healing group had the lowest median faecal calprotectin level [56.5 mg/kg] among the four groups [p ConclusionsFaecal calprotectin, when combined with serum C-reactive protein and albumin, showed acceptable performance in predicting deep healing in patients with Crohn’s disease. |
| تدمد: | 1876-4479 1873-9946 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d777b66d07a5b0bd87e2d0b39a302a72Test https://doi.org/10.1093/ecco-jcc/jjaa042Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d777b66d07a5b0bd87e2d0b39a302a72 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18764479 18739946 |
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