التفاصيل البيبلوغرافية
| العنوان: |
Serum ferritin as a predictive biomarker in COVID-19. A systematic review, meta-analysis and meta-regression analysis |
| المؤلفون: |
Kaushal, Karanvir, Kaur, Hardeep, Sarma, Phulen, Bhattacharyya, Anusuya, Sharma, Dibya Jyoti, Prajapat, Manisha, Pathak, Mona, Kothari, Ashish, Kumar, Subodh, Rana, Satyavati, Kaur, Manpreet, Prakash, Ajay, Mirza, Anissa Atif, Panda, Prasan Kumar, Vivekanandan, S., Omar, Balram Ji, Medhi, Bikash, Naithani, Manisha |
| المصدر: |
Journal of Critical Care; February 2022, Vol. 67 Issue: 1 p172-181, 10p |
| مستخلص: |
Ferritin is a known inflammatory biomarker in COVID-19. However, many factors and co-morbidities can confound the level of serum ferritin. This current metaanalysis evaluates serum ferritin level in different severity levels in COVID-19. Studies evaluating serum ferritin level in different clinical contexts (COVID-19 vs. control, mild to moderate vs. severe to critical, non-survivor vs. survivor, organ involvement, ICU and mechanical ventilation requirement) were included (total 9 literature databases searched). Metaanalysis and metaregression was carried out using metaphor “R” package. Compared to control (COVID-19 negative), higher ferritin levels were found among the COVID-19 patients [SMD −0.889 (95% C.I. −1.201, −0.577), I2 = 85%]. Severe to critical COVID-19 patients showed higher ferritin levels compared to mild to moderate COVID-19 patients [SMD 0.882 (0.738, 1.026), I2 = 85%]. In meta-regression, high heterogeneity was observed could be attributed to difference in “mean age”, and “percentage of population with concomitant co-morbidities”. Non-survivors had higher serum ferritin level compared to survivors [SMD 0.992 (0.672, 1.172), I2 = 92.33%]. In meta-regression, high heterogeneity observed could be attributed to difference in “mean age” and “percentage of male sex”. Patients requiring ICU [SMD 0.674 (0.515 to 0.833), I2 = 80%] and mechanical ventilation [SMD 0.430 (0.258, 0.602), I2 = 32%] had higher serum ferritin levels compared to those who didn't. To conclude, serum ferritin level may serve as an important biomarker which can aid in COVID-19 management. However, presence of other co-morbid conditions/confounders warrants cautious interpretation. |
| قاعدة البيانات: |
Supplemental Index |
