Disruption of the gene encoding SF‐1 alters the distribution of hypothalamic neuronal phenotypes
| العنوان: | Disruption of the gene encoding SF‐1 alters the distribution of hypothalamic neuronal phenotypes |
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| المؤلفون: | Morag J. Young, Tammy L. Dellovade, Rachael Henderson, Keith L. Parker, Elizabeth Ross, Kathleen M. Caron, Stuart A. Tobet |
| المصدر: | Journal of Comparative Neurology. 423:579-589 |
| بيانات النشر: | Wiley, 2000. |
| سنة النشر: | 2000 |
| مصطلحات موضوعية: | Steroidogenic factor 1, medicine.medical_specialty, General Neuroscience, Glutamate decarboxylase, Estrogen receptor, Biology, Neuropeptide Y receptor, Endocrinology, Ventromedial nucleus of the hypothalamus, Nuclear receptor, Internal medicine, Knockout mouse, medicine, Galanin |
| الوصف: | The ventromedial nucleus of the hypothalamus (VMH) in mice first emerges as a histologically distinct cell cluster around embryonic day 17 (E17). The earliest known marker for cells destined to form the VMH is the orphan nuclear receptor, steroidogenic factor 1 (SF-1), which can be detected in the hypothalamic primordium by E11. Strikingly, the VMH is absent in newborn SF-1 knockout mice, suggesting that SF-1 is essential for the development of VMH neurons. We reported previously that the VMH can be identified before it emerges as a histologically distinct nucleus (i.e., at E13) by the exclusion of cells that are immunoreactive for both γ-aminobutyric acid (GABA) and the synthetic enzyme, glutamic acid decarboxylase (GAD67). Subsequently, by E15, the developing VMH is demarcated further by cells that are immunoreactive for neuropeptide Y, estrogen receptor α (ERα), and galanin. It is noteworthy that the normal exclusion of GABA from the developing VMH is not seen in SF-1 knockout mice, and cells that are immunoreactive for neuropeptide Y, ERα, and galanin also are distributed aberrantly in this region. Thus, the absence of SF-1 profoundly affects the cellular architecture of the VMH from early stages in its formation. These data suggest that, directly or indirectly, SF-1 plays important roles in determining the distribution of cells in the mediobasal hypothalamus. J. Comp. Neurol. 423:579–589, 2000. © 2000 Wiley-Liss, Inc. |
| تدمد: | 1096-9861 0021-9967 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::10f2b594d24ff040c455c995f08e833fTest https://doi.org/10.1002/1096-9861Test(20000807)423:4<579::aid-cne4>3.0.co;2-# |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........10f2b594d24ff040c455c995f08e833f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10969861 00219967 |
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