دورية
Guidance for a causal comparative effectiveness analysis emulating a target trial based on big real world evidence: when to start statin treatment
| العنوان: | Guidance for a causal comparative effectiveness analysis emulating a target trial based on big real world evidence: when to start statin treatment |
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| المؤلفون: | Kuehne, Felicitas, Jahn, Beate, Conrads-Frank, Annette, Bundo, Marvin, Arvandi, Marjan, Endel, Florian, Popper, Niki, Endel, Gottfried, Urach, Christoph, Gyimesi, Michael, Murray, Eleanor J, Danaei, Goodarz, Gaziano, Thomas A, Pandya, Ankur, Siebert, Uwe |
| المصدر: | Journal of Comparative Effectiveness Research; September 2019, Vol. 8 Issue: 12 p1013-1025, 13p |
| مستخلص: | Aim:The aim of this project is to describe a causal (counterfactual) approach for analyzing when to start statin treatment to prevent cardiovascular disease using real-world evidence. Methods:We use directed acyclic graphs to operationalize and visualize the causal research question considering selection bias, potential time-independent and time-dependent confounding. We provide a study protocol following the ‘target trial’ approach and describe the data structure needed for the causal assessment. Conclusion:The study protocol can be applied to real-world data, in general. However, the structure and quality of the database play an essential role for the validity of the results, and database-specific potential for bias needs to be explicitly considered. |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | تدمد: | 20426305 20426313 |
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| DOI: | 10.2217/cer-2018-0103 |