The changes in prostate cancer and its management in the North West of England over a 10-year period
| العنوان: | The changes in prostate cancer and its management in the North West of England over a 10-year period |
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| المؤلفون: | Rachel C Esler, S Hartley, Scw Brown, Richard J. Brough, Gerald N. Collins, Andy Thompson, Adebanji Adeyoju, Andrew Sinclair, Stephen Bromage, Helene Thygesen, Michal Smolski, Rafal Turo, Paul Cleaveland, Neil Oakley |
| المصدر: | Journal of Clinical Urology. 8:315-320 |
| بيانات النشر: | SAGE Publications, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Gynecology, Prostate cancer, medicine.medical_specialty, North west, business.industry, Urology, General surgery, medicine, Surgery, Newly diagnosed, Stage (cooking), medicine.disease, business |
| الوصف: | Objectives: Our aim was to evaluate changes in prostate cancer diagnosis and management and to examine changes in the stage and grade of newly diagnosed prostate cancer in the North West of England over a 10-year period. Materials and methods: Data was collected concerning the diagnosis (including stage and grade) and management of newly diagnosed prostate cancer in the North West of England. There were three time points: 2003, 2007 and 2011 including a total of 648 patients. For assessment of median time changes Spearman’s Rank correlation test was used, for the assessment of changes in Gleason grade and clinical stage Mann–Whitney U test was used, and assessment of positive margin rates was done with Fisher’s test. Results: Median time from management decision to surgery has reduced from 46 (2003), 34 (2007) to 27 days (2011) ( p=0.074). The proportion of patients managed with active surveillance has remained relatively constant over time (18%, 16% and 21% respectively). More minimally invasive, nerve-sparing prostatectomies are now performed, and positive margin rates have significantly reduced from 53% (2003) to 23% (2011) ( pConclusion: Prostate cancer management in the North West of England has evolved over the last decade, with overall improvements in management quality. We have demonstrated an increase in the presenting stage and grade of prostate cancer over a 10-year period. |
| تدمد: | 2051-4166 2051-4158 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::3fe04afe9976421dedcf6659624f2218Test https://doi.org/10.1177/2051415815575218Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........3fe04afe9976421dedcf6659624f2218 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20514166 20514158 |
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