The MSLT is Repeatable in Narcolepsy Type 1 But Not Narcolepsy Type 2: A Retrospective Patient Study
| العنوان: | The MSLT is Repeatable in Narcolepsy Type 1 But Not Narcolepsy Type 2: A Retrospective Patient Study |
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| المؤلفون: | Fabio Pizza, Joseph Y. Cheung, Fang Han, Karel Sonka, Paul E. Peppard, Swaroop Pinto, Stefano Vandi, Giuseppe Plazzi, Emmanuel Mignot, Narong Simakajornboon, Chad Ruoff, Mali Einen, Sona Nevsimalova, David B. Rye, Lynn Marie Trotti |
| المساهمون: | Ruoff, Chad, Pizza, Fabio, Trotti, Lynn Marie, Sonka, Karel, Vandi, Stefano, Cheung, Joseph, Pinto, Swaroop, Einen, Mali, Simakajornboon, Narong, Han, Fang, Peppard, Paul, Nevsimalova, Sona, Plazzi, Giuseppe, Rye, David, Mignot, Emmanuel |
| المصدر: | Journal of Clinical Sleep Medicine. 14:65-74 |
| بيانات النشر: | American Academy of Sleep Medicine (AASM), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Male, Narcolepsy type 2, Pulmonary and Respiratory Medicine, Multiple Sleep Latency Test, MSLT, Narcolepsy type 1, medicine.medical_specialty, Pediatrics, Neurology, Cataplexy, Polysomnography, HYPOCRETIN 1, HLA-DQB1, Hypocretin-1, ICSD-3, Idiopathic hypersomnia, Neurology (clinical), Sensitivity and Specificity, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Child, Narcolepsy, Retrospective Studies, medicine.diagnostic_test, business.industry, Age Factors, Reproducibility of Results, medicine.disease, Scientific Investigations, Patient study, 030228 respiratory system, Female, medicine.symptom, business, 030217 neurology & neurosurgery |
| الوصف: | Study Objectives: To examine repeatability of Multiple Sleep Latency Test (MSLT) results in narcolepsy type 1 (NT1) and narcolepsy type 2 (NT2) according to the criteria of the International Classification of Sleep Disorders, Third Edition (ICSD-3). Methods: Repeatability of the MSLT was retrospectively evaluated in NT1 (n = 60) and NT2 (n = 54) cases, and controls (n = 15). All subjects had documented HLA-DQB1. 06:02 status and/or hypocretin-1 levels from cerebrospinal fluid. All subjects had undergone 2 MSLTs (⥠1 meeting ICSD-3 criteria for narcolepsy). Repeatability was explored in children versus adults and in those on versus not on medication(s). Subsample and multivariate analysis were performed. Results: Both MSLTs in unmedicated patients were positive for narcolepsy in 78%, 18%, and 7% of NT1, NT2, and controls, respectively. NT2 cases changed to idiopathic hypersomnia or to a negative MSLT 26% and 57% of the time, respectively. Although NT1 cases were 10 to 14 times more likely to demonstrate a second positive MSLT compared to NT2 cases (P < 10-5) and controls (P < 10-4), respectively, NT2 cases were not significantly different from controls (P = .64). Medication use (P = .009) but not adult versus children status (P = .85) significantly decreased the likelihood of a repeat positive MSLT. Conclusions: In a clinical setting, a positive MSLT for narcolepsy is a more reproducible and stable feature in NT1 than NT2. The retrospective design of this study hinders interpretation of these data, as there are many different, and possibly opposing, reasons to repeat a MSLT in NT1 versus NT2 (ie, ascertainment bias). Additional systematic MSLT repeatability studies independent of confounds are ideally needed to confirm these findings. |
| وصف الملف: | STAMPA |
| تدمد: | 1550-9397 1550-9389 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3032064f2f60f9f84f88b04485568ccTest https://doi.org/10.5664/jcsm.6882Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b3032064f2f60f9f84f88b04485568cc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15509397 15509389 |
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