التفاصيل البيبلوغرافية
| العنوان: |
Kaposi's sarcoma after T-cell costimulation blockade with abatacept in rheumatoid arthritis: a case report. |
| المؤلفون: |
Olivo, D., Grembiale, R. D., Tallarigo, F., Russo, E., De Sarro, G., Ursini, F. |
| المصدر: |
Journal of Clinical Pharmacy & Therapeutics; Jun2017, Vol. 42 Issue 3, p367-369, 3p |
| مصطلحات موضوعية: |
KAPOSI'S sarcoma, RHEUMATOID arthritis, ABATACEPT |
| مستخلص: |
What is known and objective Kaposi's sarcoma ( KS) is a malignant neoplasm caused by HHV-8, a pathogen that leads to endothelial cell transformation when host defences are weakened. Case description Here we report the first case of KS during treatment with abatacept, a biologic agent targeting T-cell costimulation. The patient was a 64-year-old female with rheumatoid arthritis who developed multiple firm, purple-reddish nodules on the dorsal aspect of the right hand. Histological examination confirmed KS. What is new and conclusion Although a direct causal relationship between KS development and abatacept treatment cannot be proved, we hypothesize a role for costimulation blockade. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
