التفاصيل البيبلوغرافية
| العنوان: |
Effects of voriconazole on tacrolimus metabolism in a kidney transplant recipient. |
| المؤلفون: |
Capone, D., Tarantino, G., Gentile, A., Sabbatini, M., Polichetti, G., Santangelo, M., Nappi, R., Ciotola, A., D'Alessandro, V., Renda, A., Basile, V., Federico, S. |
| المصدر: |
Journal of Clinical Pharmacy & Therapeutics; Feb2010, Vol. 35 Issue 1, p121-124, 4p, 1 Chart |
| مصطلحات موضوعية: |
KIDNEY transplantation, TACROLIMUS, ANTI-infective agents, IMMUNOREGULATION, DRUG interactions |
| مستخلص: |
Infection occurs frequently in the organ transplant recipients during the post-transplant period because of immunosuppression. Therefore, prophylactic antimicrobial agents are often used. The azole antifungals, widely prescribed prophylactically, are known to have many drug–drug interactions. This report presents a case of drug–drug interaction between voriconazole and tacrolimus in a kidney transplant recipient. Voriconazole treatment led to a dramatic increase in tacrolimus concentration that required its discontinuation in spite of the manufacturer’s guidelines that recommend a reduction of tacrolimus dosage by one-third. The present drug–drug interaction can be attributed to a strong inhibitory effect on cytochrome P450-3A4 activity by voriconazole. When voriconazole and tacrolimus are coadministered, close monitoring of tacrolimus blood levels is recommended as the rule-of-thumb reduction of tacrolimus dose by one-third may not be satisfactory. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
