التفاصيل البيبلوغرافية
| العنوان: |
Clinical Pharmacology of Electronic Nicotine Delivery Systems (ENDS): Implications for Benefits and Risks in the Promotion of the Combusted Tobacco Endgame. |
| المؤلفون: |
Benowitz, Neal L.1,2 Neal.Benowitz@ucsf.edu, St.Helen, Gideon1,2, Liakoni, Evangelia3 |
| المصدر: |
Journal of Clinical Pharmacology. Aug2021 Supplement S1, Vol. 61, pS18-S36. 19p. |
| مصطلحات موضوعية: |
*SMOKING cessation, *ELECTRONIC cigarettes, *PHARMACOLOGY, *NICOTINE, *TOBACCO products, *HEALTH promotion, *ENVIRONMENTAL exposure, *PHARMACODYNAMICS |
| مستخلص: |
Electronic nicotine delivery systems (ENDS) such as e‐cigarettes and heated tobacco products are novel battery‐operated devices that deliver nicotine without combustion of tobacco. Because cigarette smoking is sustained by nicotine addiction and the toxic combustion products are mainly responsible for the harmful effects of smoking, ENDS could be used to promote smoking cessation while exposing users to lower levels of toxicants compared with conventional cigarettes. The currently available evidence from clinical and observational studies indicates a potential role of e‐cigarettes as smoking cessation aids, although many continue to use e‐cigarettes long after quitting smoking. Nicotine and toxicant delivery vary considerably by device and depend on the characteristics of the e‐liquid formulation. Because smokers tend to titrate their nicotine intake to maintain their desired pharmacologic effects, device and liquid characteristics need to be considered when using ENDS as an aid to quit smoking. Factors potentially limiting their use are the currently still unknown long‐term safety of these products and concerns regarding widespread use among youth. Implications of clinical pharmacology data on ENDS for the cigarette endgame and regulation by the U.S. Food and Drug administration are discussed. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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