التفاصيل البيبلوغرافية
| العنوان: |
Increased gingival crevicular fluid levels of soluble triggering receptor expressed on myeloid cells ( sTREM) -1 in severe periodontitis. |
| المؤلفون: |
Bisson, Catherine, Massin, Frédéric, Lefevre, Pierre Arthur, Thilly, Nathalie, Miller, Neal, Gibot, Sébastien |
| المصدر: |
Journal of Clinical Periodontology; Dec2012, Vol. 39 Issue 12, p1141-1148, 8p, 3 Charts, 4 Graphs |
| مصطلحات موضوعية: |
IMMUNE system physiology, ENZYME-linked immunosorbent assay, MULTIVARIATE analysis, PERIODONTITIS, SMOKING, EQUIPMENT & supplies, SEVERITY of illness index, CASE-control method, DATA analysis software, DESCRIPTIVE statistics |
| مصطلحات جغرافية: |
FRANCE |
| مستخلص: |
Aim This study was designed to evaluate the presence of a new regulator of innate immunity in periodontitis: the soluble form of triggering receptor on myeloid cells-1 ( sTREM-1) in gingival crevicular fluid (GCF). Material and Methods GCF was collected at four sites, three pathological and one healthy from 17 patients with periodontitis, and at one healthy site from 23 control patients. An enzyme-linked immunosorbent assay (ELISA) kit was used to quantify sTREM-1 levels in collected crevicular fluid. Recorded clinical parameters were probing pocket depth (PPD), bleeding upon probing, tooth mobility, plaque index (PlI), and gingival index (GI). Results The mean sTREM-1 level in collected fluid was significantly higher in pathological sites than in healthy sites from either periodontal or control patients: 353.9 pg/ml, 50.2 pg/ml and 25.4 pg/ml respectively. Soluble TREM-1 concentration was significantly correlated with PPD. The sTREM-1 levels increased with the augmentation of the PlI and GI scores and levelled off at score 2 for both indexes. In multivariate analysis, periodontal pocket depth and smoking status were statistically associated with highest sTREM-1 concentrations. Conclusion sTREM-1 was detected in crevicular fluid and its concentration was higher in pathological sites. It could be a marker of periodontal tissue destruction. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
