Prognostic values of L-type amino acid transporter 1 and CD98hc expression in breast cancer
| العنوان: | Prognostic values of L-type amino acid transporter 1 and CD98hc expression in breast cancer |
|---|---|
| المؤلفون: | Nobuyuki Yanagisawa, Tsutomu Yoshida, Tetuo Mikami, Kiyomi Hana, Yoshiki Murakumo, Makoto Saegusa, Masaaki Ichinoe, Isao Okayasu, Hideaki Ogata, Kazutoshi Shibuya, Norihiko Sengoku, Hitoshi Endou |
| المصدر: | Journal of Clinical Pathology |
| بيانات النشر: | BMJ, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, 0301 basic medicine, medicine.medical_specialty, Fusion Regulatory Protein 1, Heavy Chain, Breast Neoplasms, L-Type Amino Acid Transporter, Large Neutral Amino Acid-Transporter 1, Pathology and Forensic Medicine, Metastasis, 03 medical and health sciences, breast cancer, 0302 clinical medicine, Breast cancer, breast pathology, Progesterone receptor, Biomarkers, Tumor, medicine, Humans, Human Epidermal Growth Factor Receptor 2, Original Research, Aged, Aged, 80 and over, Univariate analysis, business.industry, General Medicine, Middle Aged, Prognosis, medicine.disease, 030104 developmental biology, 030220 oncology & carcinogenesis, Cancer cell, histopathology, Disease Progression, Cancer research, Female, Histopathology, business |
| الوصف: | AimsL-type amino acid transporter 1 (LAT1) is a major Na+-independent neutral amino acid transporter, forming a complex with CD98hc. The aim of this study is to investigate the significance of LAT1 and CD98hc in invasive breast cancer.MethodsLAT1 and CD98hc expression was immunohistochemically assessed in 280 invasive breast cancers and analysed for association with clinicopathological features.ResultsHigh levels of LAT1 and CD98hc were observed in triple-negative breast cancers (TNBCs) possessing negative immunoreactivity with oestrogen receptor, progesterone receptor and human epidermal growth factor receptor 2, compared with non-TNBCs (NTNBCs), and were associated with lymph-node metastasis and higher nuclear grade. The high-LAT1-expression group showed a poor prognosis in NTNBC and TNBC, however, high-CD98hc-expression group showed a poor prognosis only in NTNBC. LAT1 and CD98hc expression could be the prognostic factors in univariate analyses, but not in multivariate analyses. Further, we found that invasive tumour components showed higher LAT1 and CD98hc expression than non-invasive tumour components.ConclusionsLAT1 and CD98hc may possess prognostic values in invasive breast cancer. LAT1 may be linked with cancer cell activities and disease progression in breast cancer. |
| تدمد: | 1472-4146 0021-9746 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a2549aac053cc984b2eafcd03f2a5b5Test https://doi.org/10.1136/jclinpath-2020-206457Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5a2549aac053cc984b2eafcd03f2a5b5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14724146 00219746 |
|---|