Dietary Supplement Use and Patient Outcomes in High-Risk Early-Stage Breast Cancer
| العنوان: | Dietary Supplement Use and Patient Outcomes in High-Risk Early-Stage Breast Cancer |
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| المؤلفون: | Eugen Javor, Marko Lucijanic, Marko Skelin |
| المصدر: | Journal of Clinical Oncology. 38:2110-2110 |
| بيانات النشر: | American Society of Clinical Oncology (ASCO), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Oncology, Cancer Research, medicine.medical_specialty, business.industry, Dietary supplement, Dietary Supplement Use, Patient Outcomes, High-Risk Early-Stage Breast Cancer, MEDLINE, medicine.disease, Breast cancer, Text mining, Internal medicine, medicine, Stage (cooking), business |
| الوصف: | The DELCaP trial1 reported that vitamin B12 use before and during chemotherapy was significantly associated with poorer disease-free survival (DFS ; adjusted hazard ratio [adjHR], 1.83 ; 95% CI, 1.15 to 2.92 ; P < .01) and overall survival (OS) (adjHR, 2.04 [95% CI, 1.22 to 3.40] ; P < .01). A similar association for DFS was reported for use of iron supplementation during chemotherapy (adjHR, 1.79 [95% CI, 1.20 to 2.67] ; P < .01), and for DFS and OS before treatment (DFS adjHR, 1.91 [95% CI, 0.98 to 3.70] ; OS adjHR, 1.90 [95% CI, 0.90 to 4.02] ; P = .06). t would be helpful if the authors could stratify survival analyses regarding vitamin B12 and iron use by randomized treatment arms, as well as by presence of baseline anemia, and test for the interaction among supplement use, baseline anemia or hemoglobin level, and outcomes. These would help in the interpretation of observed effects and elucidation of underlying biologic mechanisms. |
| تدمد: | 1527-7755 0732-183X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd83b37d9d4568c1988945f78cc8536Test https://doi.org/10.1200/jco.20.00091Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7cd83b37d9d4568c1988945f78cc8536 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15277755 0732183X |
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