APEX1 Expression as a Potential Diagnostic Biomarker of Clear Cell Renal Cell Carcinoma and Hepatobiliary Carcinomas
| العنوان: | APEX1 Expression as a Potential Diagnostic Biomarker of Clear Cell Renal Cell Carcinoma and Hepatobiliary Carcinomas |
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| المؤلفون: | Kwangsik Chun, In-Sang Song, Kyung-Hee Kim, Min-Kyung Yeo, Jae Sung Lim, Jimyung Kim |
| المصدر: | Journal of Clinical Medicine, Vol 8, Iss 8, p 1151 (2019) Journal of Clinical Medicine; Volume 8; Issue 8; Pages: 1151 Journal of Clinical Medicine |
| بيانات النشر: | MDPI AG, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | apurinic/apyrimidinic endonuclease 1/redox effector factor 1, hepatocellular carcinoma, cholangiocarcinoma, clear cell renal cell carcinoma, diagnosis, DNA repair, lcsh:Medicine, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Medicine, 030304 developmental biology, 0303 health sciences, business.industry, lcsh:R, General Medicine, medicine.disease, APEX1, digestive system diseases, Clear cell renal cell carcinoma, chemistry, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, Cancer cell, Cancer research, Immunohistochemistry, Biomarker (medicine), business, DNA |
| الوصف: | Apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APEX1) has been known to play key roles in DNA repair, the regulation of diverse transcriptional activity, and cellular responses to redox activity. This study aimed to examine serum APEX1 (s-APEX1) expression as a possible screening biomarker for clear cell renal cell carcinoma (ccRCC), hepatocellular carcinoma (HCC), and proximal and distal cholangiocarcinoma (CC). A total of 216 frozen serum samples were collected from 39 healthy control cases, 32 patients with ≥58 copies/mL of hepatitis B viral DNA (HBV DNA (+)), 40 ccRCC cases, 59 HCC cases, and 46 CC cases. The serum samples were examined for s-APEX1 concentration by enzyme-linked immunosorbent assay. The association of APEX1 expression with clinicopathological characteristics was also studied by immunohistochemical staining in 106 ccRCC, 131 HCC, and 32 intrahepatic CC cases. The median s-APEX1 concentrations of the HCC, CC, ccRCC, healthy control, and HBV DNA (+) groups were 0.294, 0.710, 0.474, 0.038, and 2.384 ng/mL, respectively (p < 0.001). Univariate and multivariate analyses revealed that increased cytoplasmic APEX1 expression led to a shorter disease-free survival period in HCC and CC cases. We suggest that the s-APEX1 level could be a potential diagnostic biomarker of ccRCC, HCC, and CC. Additionally, cytoplasmic APEX1 expression in cancer cells could be used to predict relapses in patients with HCC or CC. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2077-0383 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95a6efa6ece6e331c7a550505687b95cTest https://www.mdpi.com/2077-0383/8/8/1151Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....95a6efa6ece6e331c7a550505687b95c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20770383 |
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