Oral and Fecal Microbiota in Lynch Syndrome
| العنوان: | Oral and Fecal Microbiota in Lynch Syndrome |
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| المؤلفون: | Marta Puzzono, Riccardo Rosati, Ugo Elmore, Giulia Martina Cavestro, Massimo Clementi, Annalisa Russo Raucci, Nicasio Mancini, Maria Grazia Patricelli, Virginia Amato, Roberto Ferrarese, Raffaella Alessia Zuppardo, Pier Alberto Testoni, Ilaria Ditonno, Alessandro Mannucci |
| المساهمون: | Ferrarese, Roberto, Zuppardo, Raffaella Alessia, Puzzono, Marta, Mannucci, Alessandro, Amato, Virginia, Ditonno, Ilaria, Patricelli, Maria Grazia, Raucci, Annalisa Russo, Clementi, Massimo, Elmore, Ugo, Rosati, Riccardo, Testoni, Pier Alberto, Mancini, Nicasio, Cavestro, Giulia Martina |
| المصدر: | Journal of Clinical Medicine Journal of Clinical Medicine, Vol 9, Iss 2735, p 2735 (2020) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Saliva, Firmicutes, Veillonellaceae, lcsh:Medicine, Gut flora, Microbiology, 03 medical and health sciences, 0302 clinical medicine, lynch syndrome, Medicine, Feces, 030304 developmental biology, 0303 health sciences, biology, gut microbiota, business.industry, Communication, Pasteurellaceae, lcsh:R, Bacteroidetes, General Medicine, colorectal neoplasms, biology.organism_classification, oral microbiota, 030220 oncology & carcinogenesis, business, Ruminococcaceae |
| الوصف: | Background: The role of microbiota in Lynch syndrome (LS) is still under debate. We compared oral and fecal microbiota of LS saliva and stool samples with normal healthy controls (NHC). Methods: Total DNA was purified from feces and saliva to amplify the V3–V4 region of the 16s rRNA gene. Sequences with a high-quality score and length >250 bp were used for taxonomic analysis with QIIME software. Results: Compared to NHC, LS fecal samples demonstrated a statistically significant increase of Bacteroidetes and Proteobacteria and a significant decrease of Firmicutes at the phylum level and of Ruminococcaceae at the family level. Moreover, LS oral samples exhibited a statistically significant increase of Veillonellaceae and Leptotrichiaceae and a statistically significant decrease of Pasteurellaceae. A beta-diversity index allowed differentiation of the two groups. Conclusions: A peculiar microbial signature is associated with LS, similar to that of sporadic colorectal cancer and Crohn’s disease. These data suggest a possible role of proinflammatory bacteria in tumor development in a condition of genetic predisposition, such as LS. |
| تدمد: | 2077-0383 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ebbeb0751c555147c8b76334cfdaa55Test https://pubmed.ncbi.nlm.nih.gov/32847083Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5ebbeb0751c555147c8b76334cfdaa55 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20770383 |
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