التفاصيل البيبلوغرافية
| العنوان: |
Antibody Response to SARS-CoV-2 is Associated with Long-term Clinical Outcome in Patients with COVID-19: a Longitudinal Study. |
| المؤلفون: |
García-Abellán, Javier1 (AUTHOR), Padilla, Sergio1,2 (AUTHOR), Fernández-González, Marta1 (AUTHOR), García, José A.3 (AUTHOR), Agulló, Vanesa1 (AUTHOR), Andreo, María1 (AUTHOR), Ruiz, Sandra4 (AUTHOR), Galiana, Antonio5 (AUTHOR), Gutiérrez, Félix1,2 (AUTHOR) gutierrez_fel@gva.es, Masiá, Mar1,2 (AUTHOR) marmasiac@gmail.com |
| المصدر: |
Journal of Clinical Immunology. Oct2021, Vol. 41 Issue 7, p1490-1501. 12p. |
| مصطلحات موضوعية: |
*COVID-19, *SARS-CoV-2, *ANTIBODY formation, *TREATMENT effectiveness, *POST-acute COVID-19 syndrome |
| مستخلص: |
Background: The relationship of host immune response and viral replication with health outcomes in patients with COVID-19 remains to be defined. We aimed to characterize the medium and long-term clinical, virological, and serological outcomes after hospitalization for COVID-19, and to identify predictors of long-COVID. Methods: Prospective, longitudinal study conducted in COVID-19 patients confirmed by RT-PCR. Serial blood and nasopharyngeal samples (NPS) were obtained for measuring SARS-CoV-2 RNA and S-IgG/N-IgG antibodies during hospital stay, and at 1, 2, and 6 months post-discharge. Genome sequencing was performed where appropriate. Patients filled out a COVID-19 symptom questionnaire (CSQ) at 2-month and 6-month visits, and those with highest scores were characterized. Results: Of 146 patients (60% male, median age 64 years) followed-up, 20.6% required hospital readmission and 5.5% died. At 2 months and 6 months, 9.6% and 7.8% patients, respectively, reported moderate/severe persistent symptoms. SARS-CoV-2 RT-PCR was positive in NPS in 11.8% (median Ct = 38) and 3% (median Ct = 36) patients at 2 months and 6 months, respectively, but no reinfections were demonstrated. Antibody titers gradually waned, with seroreversion occurring at 6 months in 27 (27.6%) patients for N-IgG and in 6 (6%) for S-IgG. Adjusted 2-month predictors of the highest CSQ scores (OR [95%CI]) were lower peak S-IgG (0.80 [0.66–0.94]) and higher WHO severity score (2.57 [1.20–5.86]); 6-month predictors were lower peak S-IgG (0.89 [0.79–0.99]) and female sex (2.41 [1.20–4.82]); no association was found with prolonged viral RNA shedding. Conclusions: Long-COVID is associated with weak anti-SARS-CoV-2 antibody response, severity of illness, and female gender. Late clinical events and persistent symptoms in the medium and long term occur in a significant proportion of patients hospitalized for COVID-19. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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