التفاصيل البيبلوغرافية
| العنوان: |
T-Cell Response to Proinsulin and Insulin in Type 1 and Pretype 1 Diabetes. |
| المؤلفون: |
Dubois-LaForgue, Danièle, Carel, Jean-Claude, Bougnères, Pierre-François, Guillet, Jean-Gérard, Boitard, Christian |
| المصدر: |
Journal of Clinical Immunology; Mar1999, Vol. 19 Issue 2, p127-134, 8p |
| مستخلص: |
Insulin-dependent diabetes mellitus (IDDM) results from the selective destruction of pancreatic β cells by a T cell-mediated autoimmune process. Insulin and proinsulin are the only known β cell-specific autoantigens. Using short-term cultures of freshly isolated peripheral blood mononuclear cells, we evaluated T-cell responses to proinsulin and to insulin in IDDM patients and individuals at risk for IDDM. A proliferative T-cell response to proinsulin was observed in only 2 of 26 recent-onset IDDM subjects and 2 of 12 long-standing IDDM subjects and was associated with a proliferative response to insulin. In contrast, 5 of 13 islet cell autoantibody-positive first-degree relatives of IDDM patients showed a proliferative response to proinsulin alone, 3 of 13 to insulin alone, and 1 of 13 to both insulin and proinsulin. Overall, 9 of 13 ICA-positive first-degree relatives responded to either proinsulin or insulin. We observed an inverse relationship between antiinsulin antibodies and T-cell responses to insulin in ICA-positive first-degree relatives but not in long-standing IDDM patients. Our data indicate that proinsulin is a major antigen in IDDM and, further, illustrate the difference between the autoimmune response to insulin and the immune response to exogenous insulin. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
