دورية أكاديمية
Martini 3 Coarse-Grained Force Field for Cholesterol
| العنوان: | Martini 3 Coarse-Grained Force Field for Cholesterol |
|---|---|
| المؤلفون: | Borges-Araújo, L., Borges-Araújo, A., Ozturk, T., Ramirez-Echemendia, D., Fábián, B., Carpenter, T., Thallmair, S., Barnoud, J., Ingólfsson, H., Hummer, G., Tieleman, D., Marrink, S., Souza, P., Melo, M. |
| المصدر: | Journal of Chemical Theory and Computation |
| سنة النشر: | 2023 |
| المجموعة: | Max Planck Society: MPG.PuRe |
| الوصف: | Cholesterol plays a crucial role in biomembranes by regulating various properties, such as fluidity, rigidity, permeability, and organization of lipid bilayers. The latest version of the Martini model, Martini 3, offers significant improvements in interaction balance, molecular packing, and inclusion of new bead types and sizes. However, the release of the new model resulted in the need to reparameterize many core molecules, including cholesterol. Here, we describe the development and validation of a Martini 3 cholesterol model, addressing issues related to its bonded setup, shape, volume, and hydrophobicity. The proposed model mitigates some limitations of its Martini 2 predecessor while maintaining or improving the overall behavior. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | http://hdl.handle.net/21.11116/0000-000D-C3EA-FTest |
| الإتاحة: | https://doi.org/10.1021/acs.jctc.3c00547Test http://hdl.handle.net/21.11116/0000-000D-C3EA-FTest |
| رقم الانضمام: | edsbas.2E48D018 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |