BRAF mutation and RASSF1A expression in thyroid carcinoma of southern Italy
| العنوان: | BRAF mutation and RASSF1A expression in thyroid carcinoma of southern Italy |
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| المؤلفون: | Arianna Francesconi, Marina Di Domenico, Maria Antonia Carosi, Antonia Feola, Renato Franco, Luigi Nappi, Gaetano De Rosa, Pantaleo Bufo, Giuseppe Russo, Edoardo Pescarmona, Giuseppe Pannone, Gabriella Aquino, Simona Losito, Angela Santoro |
| المساهمون: | Angela, Santoro, Giuseppe, Pannone, Maria Antonia, Carosi, Arianna, Francesconi, Edoardo, Pescarmona, Giuseppe Maria, Russo, Antonia, Feola, Simona, Losito, Franco, Renato, Luigi, Nappi, Gabriella, Aquino, Gaetano De, Rosa, DI DOMENICO, Marina, Pantaleo, Bufo, Santoro, A, Pannone, G, Carosi, Ma, Francesconi, A, Pescarmona, E, Russo, Gm, Feola, A, Losito, S, Franco, R, Nappi, L, Aquino, G, DE ROSA, Gaetano, Di Domenico, M, Bufo, P. |
| المصدر: | Journal of Cellular Biochemistry. 114:1174-1182 |
| بيانات النشر: | Wiley, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Adult, Male, Proto-Oncogene Proteins B-raf, endocrine system, medicine.medical_specialty, endocrine system diseases, Thyroid Gland, Biology, Nucleic Acid Denaturation, Models, Biological, Biochemistry, Thyroid carcinoma, Internal medicine, medicine, Carcinoma, Humans, Thyroid Neoplasms, Promoter Regions, Genetic, Molecular Biology, Aged, Demography, Neoplasm Staging, Aged, 80 and over, Regulation of gene expression, Tumor Suppressor Proteins, Thyroid, Cell Biology, Methylation, DNA Methylation, Middle Aged, medicine.disease, Immunohistochemistry, Carcinoma, Papillary, Gene Expression Regulation, Neoplastic, Endocrinology, medicine.anatomical_structure, Italy, Mutation, DNA methylation, Cancer research, Female, V600E |
| الوصف: | Aim of this work is to provide a detailed comparison of clinical-pathologic features between well-differentiated and poorly differentiated tumors according to their BRAF and RASSF1A status. We analyzed RASSF1A methylation by MSP and BRAF mutation by LCRT-PCR with LightMix® kit BRAF V600E in neoplastic thyroid tissues. Immunohistochemical evaluation of RASSF1A expression was also performed by standard automated LSAB-HRP technique. An overall higher degree of RASSF1A over-expression than normal thyroid parenchyma surrounding tumors (P |
| تدمد: | 0730-2312 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ff77d7c6b05599af09c5e34d839c487Test https://doi.org/10.1002/jcb.24460Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....4ff77d7c6b05599af09c5e34d839c487 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 07302312 |
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