Novel anti‐angiogenic peptides derived From ELR‐containing CXC chemokines
| العنوان: | Novel anti‐angiogenic peptides derived From ELR‐containing CXC chemokines |
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| المؤلفون: | Emmanouil D. Karagiannis, Aleksander S. Popel |
| المصدر: | Journal of Cellular Biochemistry. 104:1356-1363 |
| بيانات النشر: | Wiley, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Umbilical Veins, Chemokine, Angiogenesis, Amino Acid Motifs, Angiogenesis Inhibitors, Biology, CXCR3, Biochemistry, Cell Movement, Humans, CXC chemokine receptors, CXCL14, CX3CL1, Molecular Biology, Cells, Cultured, Cell Proliferation, Endothelial Cells, Cell Biology, respiratory system, Peptide Fragments, In vitro, Endothelial stem cell, biology.protein, Peptides, Chemokines, CXC |
| الوصف: | Angiogenesis is tightly regulated by numerous endogenous pro- and anti-angiogenic proteins and peptides. Among these are the CXC chemokines, a set of multifunctional peptides. CXC chemokines containing the ELR motif act as pro-angiogenic agents by regulating both endothelial cell proliferation and migration. Here we show that a set of six 22-24-amino acid peptides derived from the pro-angiogenic ELR-containing CXC chemokines exhibit notable anti-proliferative and anti-migratory activity in vitro; we call these peptides chemokinostatins. The ability of the identified peptides to inhibit the basic components of angiogenesis even though they are derived from pro-angiogenic proteins contributes towards the understanding of the diverse role of the CXC chemokine family in angiogenesis. |
| تدمد: | 1097-4644 0730-2312 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac3e586e03fd83512498bea8ceb7f0b1Test https://doi.org/10.1002/jcb.21712Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....ac3e586e03fd83512498bea8ceb7f0b1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10974644 07302312 |
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