Developmental and tissue expression patterns of histone macroH2A1 subtypes
| العنوان: | Developmental and tissue expression patterns of histone macroH2A1 subtypes |
|---|---|
| المؤلفون: | John R. Pehrson, Carl Costanzi, Chhaya Dharia |
| المصدر: | Journal of Cellular Biochemistry. 65:107-113 |
| بيانات النشر: | Wiley, 1997. |
| سنة النشر: | 1997 |
| مصطلحات موضوعية: | biology, Gene Expression Regulation, Developmental, Cell Biology, Biochemistry, Molecular biology, Embryonic stem cell, Nucleosomes, Rats, Chromatin, Histones, Mice, Histone, Complementary DNA, Histone H2A, biology.protein, Animals, Nucleosome, Coding region, Tissue Distribution, Rabbits, Cloning, Molecular, Molecular Biology, Leukemia inhibitory factor |
| الوصف: | MacroH2A is a novel nucleosomal core histone that contains a large nonhistone region and a region that closely resembles a full length histone H2A. We have cloned a cDNA that contains the entire coding region of macroH2A1.2, one of the two identified subtypes of macroH2A1. MacroH2A1.2 was found to differ from the other known subtype, macroH2A1.1, in a single segment of the nonhistone region. MacroH2A1 specific antibodies revealed relatively high levels of both subtypes in adult liver and kidney. MacroH2A1.1 was much lower in fetal liver and kidney in comparison to their adult counterparts, and was not detected in adult thymus and testis, tissues with active cell division and differentiation. Both subtypes were present at very low levels or absent from mouse embryonic stem cells maintained in an undifferentiated state by growth in the presence of leukemia inhibitory factor. MacroH2A1.2 increased when the embryonic stem cells were induced to differentiate in vitro, while macroH2A1.1 remained undetectable. These results support the idea that macroH2A1.1 and macroH2A1.2 are functionally distinct, and suggest that changes in their expression may play a role in developmentally regulated changes in chromatin structure and function. J. Cell. Biochem. 65:107–113. © 1997 Wiley-Liss, Inc. |
| تدمد: | 1097-4644 0730-2312 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea74b38f608e148598a704f2e4342768Test https://doi.org/10.1002Test/(sici)1097-4644(199704)65:1<107::aid-jcb11>3.0.co;2-h |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....ea74b38f608e148598a704f2e4342768 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10974644 07302312 |
|---|