RNA-binding proteins implicated in the hypoxic response
| العنوان: | RNA-binding proteins implicated in the hypoxic response |
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| المؤلفون: | Myriam Gorospe, Kotb Abdelmohsen, Kiyoshi Masuda |
| المصدر: | Journal of Cellular and Molecular Medicine |
| بيانات النشر: | John Wiley & Sons, Ltd, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | oxygen tension, ELAV-Like Protein 1, Reviews, RNA-binding protein, Biology, Heterogeneous ribonucleoprotein particle, mRNA turnover, stress, untranslated regions, Gene expression, Animals, Humans, Regulation of gene expression, Messenger RNA, translational control, RNA-Binding Proteins, Translation (biology), Cell Biology, Molecular biology, Cell Hypoxia, Oxygen tension, Cell biology, ribonucleoprotein complex, ELAV Proteins, Gene Expression Regulation, Antigens, Surface, Molecular Medicine, post-transcriptional gene regulation |
| الوصف: | In cells responding to low oxygen levels, gene expression patterns are strongly influenced by post-transcriptional processes. RNA-binding proteins (RBPs) are pivotal regulators of gene expression in response to numerous stresses, including hypoxia. Here, we review the RBPs that modulate mRNA turnover and translation in response to hypoxic challenge. The RBPs HuR (human antigen R) and PTB (polypyrimidine tract-binding protein) associate with mRNAs encoding hypoxia-response proteins such as HIF-1alpha and VEGF mRNAs, enhance their expression after hypoxia and play a major role in establishing hypoxic gene expression patterns. Additional RBPs such as iron-response element-binding proteins (IRPs), cytoplasmic polyadenylation-element-binding proteins (CPEBs) and several heterogeneous nuclear ribonucleoproteins (hnRNPs) also bind to hypoxia-regulated transcripts and modulate the levels of the encoded proteins. We discuss the efficient regulation of hypoxic gene expression by RBPs and the mounting interest in targeting hypoxia-regulatory RBPs in diseases with aberrant hypoxic responses. |
| اللغة: | English |
| تدمد: | 1582-4934 1582-1838 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0d8441cbe57e41bd92019aae18cec3eTest http://europepmc.org/articles/PMC2832090Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c0d8441cbe57e41bd92019aae18cec3e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15824934 15821838 |
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