Integrin‐associated molecules and signalling cross talking in osteoclast cytoskeleton regulation
| العنوان: | Integrin‐associated molecules and signalling cross talking in osteoclast cytoskeleton regulation |
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| المؤلفون: | Baorong He, Biao Wang, Lingbo Kong, Dingjun Hao, Liang Yan, Xiaobin Yang |
| المصدر: | Journal of Cellular and Molecular Medicine |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Integrins, Podosome, integrin, Integrin, Reviews, Osteoclasts, Review, Bone resorption, Mice, Phosphatidylinositol 3-Kinases, 03 medical and health sciences, 0302 clinical medicine, Osteogenesis, Osteoclast, Organelle, medicine, Animals, Humans, Syk Kinase, Bone Resorption, Cytoskeleton, Actin, biology, podosomes, Chemistry, Macrophage Colony-Stimulating Factor, RANK Ligand, cytoskeleton, Cell Biology, Cell biology, 030104 developmental biology, medicine.anatomical_structure, RANKL, 030220 oncology & carcinogenesis, osteoclast, biology.protein, Molecular Medicine, Signal Transduction |
| الوصف: | In the ageing skeleton, the balance of bone reconstruction could commonly be broken by the increasing of bone resorption and decreasing of bone formation. Consequently, the bone resorption gradually occupies a dominant status. During this imbalance process, osteoclast is unique cell linage act the bone resorptive biological activity, which is a highly differentiated ultimate cell derived from monocyte/macrophage. The erosive function of osteoclasts is that they have to adhere the bone matrix and migrate along it, in which adhesive cytoskeleton recombination of osteoclast is essential. In that, the podosome is a membrane binding microdomain organelle, based on dynamic actin, which forms a cytoskeleton superstructure connected with the plasma membrane. Otherwise, as the main adhesive protein, integrin regulates the formation of podosome and cytoskeleton, which collaborates with the various molecules including: c‐Cbl, p130Cas, c‐Src and Pyk2, through several signalling cascades cross talking, including: M‐CSF and RANKL. In our current study, we discuss the role of integrin and associated molecules in osteoclastogenesis cytoskeletal, especially podosomes, regulation and relevant signalling cascades cross talking. |
| تدمد: | 1582-4934 1582-1838 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3f3d6d605d15fdc81e30b0f3cf4517cTest https://doi.org/10.1111/jcmm.15052Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a3f3d6d605d15fdc81e30b0f3cf4517c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15824934 15821838 |
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