Glucose uptake in brown fat cells is dependent on mTOR complex 2-promoted GLUT1 translocation
| العنوان: | Glucose uptake in brown fat cells is dependent on mTOR complex 2-promoted GLUT1 translocation |
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| المؤلفون: | Olsen, Jessica M., Sato, Masaaki, Dallner, Olof S., Sandström, Anna L., Pisani, Didier F., Jean-Claude, Chambard, Amri, Ez-Zoubir, Hutchinson, Dana S., Bengtsson, Tore |
| المصدر: | Journal of Cell Biology. 207(3) |
| مصطلحات موضوعية: | fysiologi, Physiology |
| الوصف: | Brown adipose tissue is the primary site for thermogenesis and can consume, in addition to free fatty acids, a very high amount of glucose from the blood, which can both acutely and chronically affect glucose homeostasis. Here, we show that mechanistic target of rapamycin (mTOR) complex 2 has a novel role in β3-adrenoceptor-stimulated glucose uptake in brown adipose tissue. We show that β3-adrenoceptors stimulate glucose uptake in brown adipose tissue via a signaling pathway that is comprised of two different parts: one part dependent on cAMP-mediated increases in GLUT1 transcription and de novo synthesis of GLUT1 and another part dependent on mTOR complex 2-stimulated translocation of newly synthesized GLUT1 to the plasma membrane, leading to increased glucose uptake. Both parts are essential for β3-adrenoceptor-stimulated glucose uptake. Importantly, the effect of β3-adrenoceptor on mTOR complex 2 is independent of the classical insulin-phosphoinositide 3-kinase-Akt pathway, highlighting a novel mechanism of mTOR complex 2 activation. |
| وصف الملف: | |
| الوصول الحر: | https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-143136Test https://doi.org/10.1083/jcb.201403080Test |
| قاعدة البيانات: | SwePub |
| تدمد: | 00219525 15408140 |
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| DOI: | 10.1083/jcb.201403080 |