Horizontal tumor extent (HZTE) has limited prognostic significance in 2018 FIGO stage I endocervical adenocarcinoma (ECA): a retrospective study of 416 cases
| العنوان: | Horizontal tumor extent (HZTE) has limited prognostic significance in 2018 FIGO stage I endocervical adenocarcinoma (ECA): a retrospective study of 416 cases |
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| المؤلفون: | Georgia Karpathiou, Esther Guerra Fernandez, Andres A. Roma, Simona Stolnicu, Graziele Bovolim, Anna Pesci, Robert A. Soslow, Louise De Brot, Esther Oliva, Lien Hoang, Pavel Dundr, Ana Félix, Glauco Baiocchi, Maria José Brito, Antonio Ieni, Kay J. Park, Sofia Lerias, Takako Kyiokawa, Nadeem R. Abu-Rustum, Carlos Parra-Herran, Noorah Almadani |
| المصدر: | J Cancer Res Clin Oncol |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Oncology, Cancer Research, medicine.medical_specialty, Multivariate analysis, Uterine Cervical Neoplasms, Adenocarcinoma, Hysterectomy, Article, Figo staging, Recurrence free survival, Internal medicine, Humans, Medicine, Stage (cooking), Aged, Retrospective Studies, Univariate analysis, business.industry, Retrospective cohort study, General Medicine, Middle Aged, Prognosis, Cervical cancer staging, Survival Rate, Endocervical Adenocarcinoma, Endocervical adenocarcinoma, FIGO, Horizontal tumor extent, Management, Prognostic significance, Stage, Female, business, Follow-Up Studies |
| الوصف: | PURPOSE: The 2018 International Federation of Gynecology and Obstetrics (FIGO) update on cervical cancer staging eliminated horizontal tumor extent (HZTE) as a staging parameter in stage IA (microscopic) disease. We aimed to determine whether HZTE correlates with outcomes in early stage ECAs and FIGO should reinstate HZTE as a staging parameter in futures updates. METHODS: We retrospectively analyzed 416 FIGO 2009 stage I ECAs from 17 institutions and re-assigned stage using FIGO 2018. Correlation between HZTE, overall (OS) and recurrence free survival (RFS) was performed using univariable and multivariable analyses. RESULTS: Re-staging 416 cases resulted in 126 (30.3%) IA and 290 (69.7%) IB cases; 85 (67.5%) IA tumors had HZTE ≤7mm, while 41 (32.5%) were >7mm; 32 (11%) IB tumors had HZTE ≤7mm, while 258 (89%) were >7mm (p=0.0001). Four (3.2%) IA (1 IA1, 3 IA2) patients developed recurrence (3 ≤7mm, 1 >7mm) compared to 41 (14.1%) IB patients (p=0.002). Fourteen IB and no IA patients died of disease (8 IB1, 1 ≤7mm). Cox univariate analysis demonstrated that only RFS is significantly influenced by HZTE (p=0.01), while OS and RFS were not influenced by HZTE on multivariate analysis. CONCLUSION: HZTE has limited prognostic value in early stage ECAs and is only associated with RFS on univariate but not multivariate analysis. HZTE does not improve prognostication of patients with stage I ECAs as per 2018 FIGO staging. Consequently, the rationale to remove this variable from FIGO staging is justified for ECAs. |
| تدمد: | 1432-1335 0171-5216 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bee7e5d341b9874e0222d3ed81562adeTest https://doi.org/10.1007/s00432-021-03850-wTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bee7e5d341b9874e0222d3ed81562ade |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14321335 01715216 |
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