التفاصيل البيبلوغرافية
| العنوان: |
Detection of metastases using circulating tumour DNA in uveal melanoma. |
| المؤلفون: |
Beasley, Aaron B., de Bruyn, Daniël P., Calapre, Leslie, Al-Ogaili, Zeyad, Isaacs, Timothy W., Bentel, Jacqueline, Reid, Anna L., Dwarkasing, Roy S., Pereira, Michelle R., Khattak, Muhammad A., Meniawy, Tarek M., Millward, Michael, Brosens, Erwin, de Klein, Annelies, Chen, Fred K., Kiliҫ, Emine, Gray, Elin S. |
| المصدر: |
Journal of Cancer Research & Clinical Oncology; Nov2023, Vol. 149 Issue 16, p14953-14963, 11p |
| مصطلحات موضوعية: |
CIRCULATING tumor DNA, UVEA cancer, MELANOMA, METASTASIS, PATIENT monitoring, MULTIVARIATE analysis, OVERALL survival |
| مستخلص: |
Background: Approximately 50% of uveal melanoma (UM) patients will develop metastatic disease depending on the genetic features of the primary tumour. Patients need 3–12 monthly scans, depending on their prognosis, which is costly and often non-specific. Circulating tumour DNA (ctDNA) quantification could serve as a test to detect and monitor patients for early signs of metastasis and therapeutic response. Methods: We assessed ctDNA as a biomarker in three distinct UM cohorts using droplet-digital PCR: (A) a retrospective analysis of primary UM patients to predict metastases; (B) a prospective analysis of UM patients after resolution of their primary tumour for early detection of metastases; and (C) monitoring treatment response in metastatic UM patients. Results: Cohort A: ctDNA levels were not associated with the development of metastases. Cohort B: ctDNA was detected in 17/25 (68%) with radiological diagnosis of metastases. ctDNA was the strongest predictor of overall survival in a multivariate analysis (HR = 15.8, 95% CI 1.7–151.2, p = 0.017). Cohort C: ctDNA monitoring of patients undergoing immunotherapy revealed a reduction in the levels of ctDNA in patients with combination immunotherapy. Conclusions: Our proof-of-concept study shows the biomarker feasibility potential of ctDNA monitoring in for the clinical management of uveal melanoma patients. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Cancer Research & Clinical Oncology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder