Serum sclerostin levels in healthy men over 50 years of age
| العنوان: | Serum sclerostin levels in healthy men over 50 years of age |
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| المؤلفون: | Harjit Pal Bhattoa, John Wamwaki, Roza Foldesi, Edit Kalina, Péter Antal-Szalmás, Adam Balogh |
| المصدر: | Journal of Bone and Mineral Metabolism. 31:579-584 |
| بيانات النشر: | Springer Science and Business Media LLC, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Genetic Markers, Male, Aging, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Osteocalcin, Renal function, Parathyroid hormone, Bone remodeling, chemistry.chemical_compound, Endocrinology, Bone Density, Internal medicine, medicine, Humans, Orthopedics and Sports Medicine, Vitamin D, Adaptor Proteins, Signal Transducing, Aged, Aged, 80 and over, Bone mineral, biology, business.industry, General Medicine, Middle Aged, Cystatin C, chemistry, Parathyroid Hormone, Bone Morphogenetic Proteins, biology.protein, Population study, Sclerostin, business |
| الوصف: | The aim of this study is to evaluate the relationship of serum sclerostin levels with age, cystatin C, bone mineral density (BMD) and biochemical markers of bone turnover in healthy Hungarian men >50 years of age. We determined serum levels of sclerostin and examined its relationship to age, cystatin C, osteocalcin, C-terminal telopeptides of type-I collagen, procollagen type 1 amino-terminal propeptide, 25-hydroxyvitamin D, parathyroid hormone, and L1–L4 (LS) and femur neck (FN) BMD data available from 194 randomly selected ambulatory men belonging to the HunMen cohort. In the study population as a whole [n = 194; age (median, range) 59 (51–81) years], statistically significant correlation was found between sclerostin and age (r = 0.211; p = 0.003), cystatin C (r = 0.246; p = 0.001), FN BMD (r = 0.147; p = 0.041) and LS BMD (r = 0.169; p = 0.019). Compared to middle-aged men (age ≤59 years, n = 98), elderly men (age >59 years, n = 96) had significantly higher serum sclerostin levels (67.8 ± 15.9 vs 63.5 ± 14 pmol/L; p = 0.047). Among men with normal (T score >−1.0) FN BMD, the elderly had significantly higher serum sclerostin levels compared to the middle-aged men (70.4 ± 17 vs 63.9 ± 11.5 pmol/L; p = 0.019). Furthermore, among the elderly men cystatin C was the only significant predictor of serum sclerostin levels (standardized regression coefficient (β) = 0.487; p |
| تدمد: | 1435-5604 0914-8779 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a551b2d0dd074a579812e075f92aeb4Test https://doi.org/10.1007/s00774-013-0451-zTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....7a551b2d0dd074a579812e075f92aeb4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14355604 09148779 |
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