التفاصيل البيبلوغرافية
| العنوان: |
Chimeric Antigen Receptor-Engineered T Cells for Immunotherapy of Cancer. |
| المؤلفون: |
Cartellieri, Marc, Bachmann, Michael, Feldmann, Anja, Bippes, Claudia, Stamova, Slava, Wehner, Rebekka, Temme, Achim, Schmitz, Marc |
| المصدر: |
Journal of Biomedicine & Biotechnology; 2010, p1-13, 13p, 3 Diagrams |
| مصطلحات موضوعية: |
LYMPHOCYTE classification, CANCER treatment, ANTINEOPLASTIC agents, T cells, CELL receptors, CELLULAR immunity, CANCER patients |
| مستخلص: |
CD4+ and CD8+ T lymphocytes are powerful components of adaptive immunity, which essentially contribute to the elimination of tumors. Due to their cytotoxic capacity, T cells emerged as attractive candidates for specific immunotherapy of cancer. A promising approach is the genetic modification of T cells with chimeric antigen receptors (CARs). First generation CARs consist of a binding moiety specifically recognizing a tumor cell surface antigen and a lymphocyte activating signaling chain. The CAR-mediated recognition induces cytokine production and tumor-directed cytotoxicity of T cells. Second and third generation CARs include signal sequences from various costimulatory molecules resulting in enhanced T-cell persistence and sustained antitumor reaction. Clinical trials revealed that the adoptive transfer of T cells engineered with first generation CARs represents a feasible concept for the induction of clinical responses in some tumor patients. However, further improvement is required, which may be achieved by second or third generation CAR-engrafted T cells. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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