التفاصيل البيبلوغرافية
| العنوان: |
Mechanism of MTA1 Protein Overexpression-linked Invasion MTA1 REGULATION OF HYALURONAN-MEDIATED MOTILITY RECEPTOR (HMMR) EXPRESSION AND FUNCTION. |
| المؤلفون: |
Sankaran, Deivendran1, Pakala, Suresh B.2, Nair, Vasudha S.2, Sirigiri, Divijendra Natha Reddy2, Cyanam, Dinesh2, Ngoc-Han Ha2, Da-Qiang Li2, Santhoshkumar, T. R.1, Pillai, M. Radhakrishna1 mrpillai@rgcb.res.in, Kumar, Rakesh1,2 bcmrxk@gwumc.edu |
| المصدر: |
Journal of Biological Chemistry. 2/17/2012, Vol. 287 Issue 8, p5483-5491. 10p. |
| مصطلحات موضوعية: |
*BREAST cancer treatment, *SMALL interfering RNA, *CELL migration, *METASTASIS, *TUMOR antigens, *HYALURONIC acid |
| مستخلص: |
Even though the hyaluronan-mediated motility receptor (HMMR), a cell surface oncogenic protein, is widely up-regulated in human cancers and correlates well with cell motility and invasion, the underlying molecular and nature of its putative upstream regulation remain unknown. Here, we found for the first time that MTA1 (metastatic tumor antigen 1), a master chromatin modifier, regulates the expression of HMMR and, consequently, its function in breast cancer cell motility and invasiveness. We recognized a positive correlation between the levels of MTA1 and HMMR in human cancer. Furthermore, MTA1is required for optimal expression ofHMMR.The underlying mechanism includes interaction of the MTA1.RNA polymerase II.c-Jun coactivator complex with the HMMR promoter to stimulates its transcription. Accordingly, selective siRNA-mediated knockdown of HMMR in breast cancer cells substantially reduces the invasion and migration of cells. These findings reveal a regulatory role for MTA1 as an upstream coactivator of HMMR expression and resulting biological phenotypes. [ABSTRACT FROM AUTHOR] |
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