التفاصيل البيبلوغرافية
| العنوان: |
Modelling of Search and Recognition for Target Cells by Protein-Linear Polyelectrolyte Conjugates. |
| المؤلفون: |
Kabanov, V. A., Yaroslavov, A. A., Boronina, O. V., Sukhishvili, S. A., Nazarova, I. R. |
| المصدر: |
Journal of Bioactive & Compatible Polymers; Jan1995, Vol. 10 Issue 1, p41-50, 10p |
| مستخلص: |
The interaction of α-chymotrypsin covalently bound to quaternized poly(4-vinylpyridine) with oppositely charged latex particles was investigated and compared with that of free a-chymotrypsin. The free enzyme and the corresponding polymer conjugates were added to a mixture of two latexes: one coated with bovine serum albumin and the other with specific inhibitor of a- chymotrypsin. The polycations themselves were found to be nonselectively adsorbed on oppositely charged latex surfaces. However, the ca-chymotrypsin-polycation conjugates, as well as the free enzyme, were selectively adsorbed on the latex surfaces coated with the enzyme inhibitor. The results are considered to mimic the search and recognition mechanism for target cells by polyelectrolytes carrying a specific vector moiety. [ABSTRACT FROM PUBLISHER] |
|
Copyright of Journal of Bioactive & Compatible Polymers is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
