التفاصيل البيبلوغرافية
| العنوان: |
Associations among the opioid receptor gene (OPRM1) A118G polymorphism, psychiatric symptoms, and quantitative EEG in Korean males with gambling disorder: A pilot study. |
| المؤلفون: |
Kim, Kyoung Min, Choi, Sam-Wook, Kim, Dohyun, Lee, Jaewon, Kim, Jun Won |
| المصدر: |
Journal of Behavioral Addictions; 2019, Vol. 8 Issue 3, p463-470, 8p |
| مصطلحات موضوعية: |
OPIOID receptors, GAMBLING behavior, RESTRICTION fragment length polymorphisms, COMPULSIVE gambling, SINGLE nucleotide polymorphisms, PILOT projects, POLYMERASE chain reaction |
| مستخلص: |
A single nucleotide polymorphism of A118G (SNP; rs1799971) in the opioid receptor μ-1 (OPRM1) gene is a missense variant that influences the affinity of μ-opioid receptors. This study aimed to investigate the associations among the A118G polymorphism in the OPRM1 gene, psychiatric symptoms, and quantitative electroencephalography (qEEG) findings in patients with gambling disorder. Fifty-five male patients with gambling disorder aged between 18 and 65 years old participated in the study. The A118G polymorphism was genotyped into the AA, GA, and GG groups by the polymerase chain reaction/restriction fragment length polymorphism method. Resting-state qEEG was recorded with the eyes closed, and the absolute power of the delta (1–4 Hz), theta (4–8 Hz), alpha (8–12 Hz), and beta (12–30 Hz) frequency bands was analyzed. Psychiatric symptoms, including depression, anxiety, impulsivity and severity of gambling, were assessed by a self-rating scale. There were no significant differences in psychiatric symptoms among the three genotype groups (AA, GA, and GG). However, the frequency band power of qEEG showed significant differences among the three genotype groups. The absolute power of the beta and theta bands in the frontal lobe was higher in G allele carriers. Based on the findings of this study, the polymorphism in the OPRM1 gene might affect the neurophysiological process in patients with gambling disorder. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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