دورية أكاديمية
Altered Developmental Trajectory in Male and Female Rats in a Prenatal Valproic Acid Exposure Model of Autism Spectrum Disorder
| العنوان: | Altered Developmental Trajectory in Male and Female Rats in a Prenatal Valproic Acid Exposure Model of Autism Spectrum Disorder |
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| اللغة: | English |
| المؤلفون: | Anshu, Kumari, Nair, Ajay Kumar, Srinath, Shoba, Laxmi, T. Rao (ORCID |
| المصدر: | Journal of Autism and Developmental Disorders. Nov 2023 53(11):4390-4411. |
| الإتاحة: | Springer. Available from: Springer Nature. One New York Plaza, Suite 4600, New York, NY 10004. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-460-1700; e-mail: customerservice@springernature.com; Web site: https://link.springer.comTest/ |
| تمت مراجعته من قبل الزملاء: | Y |
| Page Count: | 22 |
| تاريخ النشر: | 2023 |
| نوع الوثيقة: | Journal Articles Reports - Research |
| الواصفات: | Autism Spectrum Disorders, Animals, Perceptual Motor Learning, Psychomotor Skills, Cognitive Processes, Gender Differences |
| DOI: | 10.1007/s10803-022-05684-y |
| تدمد: | 0162-3257 1573-3432 |
| مستخلص: | Early motor and sensory developmental delays precede Autism Spectrum Disorder (ASD) diagnosis and may serve as early indicators of ASD. The literature on sensorimotor development in animal models is sparse, male centered, and has mixed findings. We characterized early development in a prenatal valproic acid (VPA) model of ASD and found sex-specific developmental delays in VPA rats. We created a developmental composite score combining 15 test readouts, yielding a reliable gestalt measure spanning physical, sensory, and motor development, that effectively discriminated between VPA and control groups. Considering the heterogeneity in ASD phenotype, the developmental composite offers a robust metric that can enable comparison across different animal models of ASD and can serve as an outcome measure for early intervention studies. |
| Abstractor: | As Provided |
| Entry Date: | 2023 |
| رقم الانضمام: | EJ1394300 |
| قاعدة البيانات: | ERIC |
| تدمد: | 0162-3257 1573-3432 |
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| DOI: | 10.1007/s10803-022-05684-y |