Triterpenoid saponins from the rhizomes of Anemone flaccida and their inhibitory activities on LPS-induced NO production in macrophage RAW264.7 cells
| العنوان: | Triterpenoid saponins from the rhizomes of Anemone flaccida and their inhibitory activities on LPS-induced NO production in macrophage RAW264.7 cells |
|---|---|
| المؤلفون: | Qing Liu, Jing-Qun Tang, Ying Wang, Wen-Cai Ye, Hui-Nan Zhao, Yao-Lan Li, Xiao-Jun Huang, Chun-Lin Fan, Man-Mei Li, Pei Hong |
| المصدر: | Journal of Asian Natural Products Research. 16:910-921 |
| بيانات النشر: | Informa UK Limited, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Lipopolysaccharides, medicine.drug_class, Anti-Inflammatory Agents, Pharmaceutical Science, Ranunculaceae, Nitric Oxide, Inhibitory postsynaptic potential, complex mixtures, Anti-inflammatory, Analytical Chemistry, Nitric oxide, Mice, chemistry.chemical_compound, Anemone, parasitic diseases, Drug Discovery, Botany, medicine, Animals, Humans, Macrophage, Triterpenoid saponin, Pharmacology, chemistry.chemical_classification, Molecular Structure, biology, Traditional medicine, Macrophages, Organic Chemistry, General Medicine, Saponins, musculoskeletal system, biology.organism_classification, Antineoplastic Agents, Phytogenic, Triterpenes, In vitro, Rhizome, carbohydrates (lipids), Complementary and alternative medicine, chemistry, Molecular Medicine, Drugs, Chinese Herbal |
| الوصف: | A new ursane-type triterpenoid saponin, flaccidoside IV (1), and three new oleanane-type triterpenoid saponins, flaccidosides V-VII (2-4), along with 17 known saponins (5-21), were isolated from the rhizomes of Anemone flaccida. The structures of the new triterpenoid saponins were determined based on spectroscopic analyses and chemical methods. All the isolated saponins were tested for their inhibitory activities on lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophages, and several bisdesmosidic oleanane-type triterpenoid saponins (2, 7, and 10) showed significant inhibitory activities, which indicated they had potential anti-inflammatory activities under their noncytotoxic concentrations in vitro. |
| تدمد: | 1477-2213 1028-6020 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a70a37fabdc9c62b4b064063418c37eTest https://doi.org/10.1080/10286020.2014.954554Test |
| رقم الانضمام: | edsair.doi.dedup.....2a70a37fabdc9c62b4b064063418c37e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14772213 10286020 |
|---|