التفاصيل البيبلوغرافية
| العنوان: |
New sesquiterpenoid derivatives from Solanum lyratum and their cytotoxicities. |
| المؤلفون: |
Li, Gui-Sheng1 (AUTHOR), Yao, Fang1 (AUTHOR), Zhang, Lei1 (AUTHOR), Yue, Xi-Dian1 (AUTHOR), Dai, Sheng-Jun1 (AUTHOR) daishengjun_9@hotmail.com |
| المصدر: |
Journal of Asian Natural Products Research. Feb2014, Vol. 16 Issue 2, p129-134. 6p. |
| مصطلحات موضوعية: |
*CHROMATOGRAPHIC analysis, *ANIMAL experimentation, *CELL culture, *MASS spectrometry, *MICE, *MOLECULAR structure, *NUCLEAR magnetic resonance spectroscopy, *PHARMACEUTICAL chemistry, *RESEARCH funding, *TERPENES, *TOXICITY testing, *PLANT extracts, *DESCRIPTIVE statistics, *IN vitro studies |
| مستخلص: |
Three new sesquiterpenoid isopropylidene derivatives, named solajiangxins H and I (1 and 2) and 7-hydroxylsolajiangxin I (3), were isolated from the whole plant of Solanum lyratum. Their structures were elucidated on the basis of integrated spectroscopic techniques, mainly HR-FAB-MS, 1D NMR, and 2D NMR (1H–1H COSY, HMQC, HMBC, and NOESY). In vitro, compounds 1–3 were found to show significant cytotoxicity against three cancer cells (P-388, HONE-1, and HT-29), and gave IC50 values in the range of 3.2–7.7 μM. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
