التفاصيل البيبلوغرافية
| العنوان: |
Type 2 diabetes exacerbates changes in blood pressure-independent arterial stiffness: cross-sectional and longitudinal evidence from the SUMMIT study. |
| المؤلفون: |
Aizawa, Kunihiko, Gates, Phillip E., Mawson, David M., Casanova, Francesco, Gooding, Kim M., Hope, Suzy V., Goncalves, Isabel, Nilsson, Jan, Khan, Faisel, Colhoun, Helen M., Natali, Andrea, Palombo, Carlo, Shore, Angela C. |
| المصدر: |
Journal of Applied Physiology; Jan2024, Vol. 136 Issue 1, p13-22, 10p |
| مصطلحات موضوعية: |
ARTERIAL diseases, TYPE 2 diabetes, PULSE wave analysis, BLOOD pressure, HEART beat |
| مستخلص: |
Greater central artery stiffness is observed in people with type 2 diabetes (T2DM). Elevated blood pressure (BP) and altered arterial wall structure/composition in T2DM are generally considered as main drivers for this alteration. However, because conventional arterial stiffness measures are BP-dependent and as such an influence of BP remains in a measure, it is unclear if greater central artery stiffness is a function of greater BP, or due to changes in the structure and composition of the arterial wall. We aimed to measure BP-independent arterial stiffness (β0) cross-sectionally and longitudinally in T2DM. We studied 753 adults with T2DM (DMþ) and 436 adults without (DM-) at baseline (Phase 1), and 310 DM+ and 210 DM-adults at 3-yr follow-up (Phase 2). We measured carotid-femoral pulse wave velocity and used it to calculate β0. In Phase 1, β0 was significantly greater in DM+ than DM- after adjusting for age and sex [27.5 (26.6-28.3) vs. 23.6 (22.4-24.8) au, P < 0.001]. Partial correlation analyses after controlling for age and sex showed that β0 was significantly associated with hemoglobin A1c (r = 0.15 P < 0.001) and heart rate [(HR): r = 0.23 P < 0.001)] in DM+. In Phase 2, percentage-change in β0 was significantly greater in DM+ than DM- [19.5 (14.9-24.0) vs. 5.0 (-0.6 to 10.6) %, P < 0.001] after adjusting for age, sex, and baseline β0. β0 was greater in DM+ than DM- and increased much more in DM+ than in DM- over 3 yr. This suggests that T2DM exacerbates BP-independent arterial stiffness and may have a complemental utility to existing arterial stiffness indices. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
