Contribution of exertional hyperthermia to sympathoadrenal-mediated lymphocyte subset redistribution
| العنوان: | Contribution of exertional hyperthermia to sympathoadrenal-mediated lymphocyte subset redistribution |
|---|---|
| المؤلفون: | Greg A. Gannon, Shawn G. Rhind, Manny W. Radomski, Jiri Zamecnik, Valéria Maria Natale, Alain Buguet, Roy J. Shephard, Ingrid K. M. Brenner, Yvonne D. Severs, Pang N. Shek |
| المصدر: | Journal of Applied Physiology. 87:1178-1185 |
| بيانات النشر: | American Physiological Society, 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | Adult, Male, Hyperthermia, medicine.medical_specialty, Sympathetic Nervous System, Hydrocortisone, Physiology, Lymphocyte, Physical exercise, Body Temperature, Immunophenotyping, Hemoglobins, Catecholamines, T-Lymphocyte Subsets, Physiology (medical), Internal medicine, Adrenal Glands, Immersion, medicine, Humans, Sympathoadrenal system, Leukocytosis, Exercise, Blood Volume, business.industry, Thermoregulation, medicine.disease, Endocrinology, medicine.anatomical_structure, Epinephrine, Hematocrit, Immunology, Exercise Test, medicine.symptom, business, Hormone, medicine.drug |
| الوصف: | The contribution of hyperthermia to the differential leukocytosis of exercise remains obscure. This study examined changes in circulating sympathoadrenal hormone concentrations and patterns of leukocyte and lymphocyte subset (CD3+, CD4+, CD8+, CD19+, CD3−16+/56+) redistribution during exercise, with and without a significant rise of rectal temperature (Tre). Ten healthy men [age 26.9 ± 5.7 (SD) yr, body mass 76.0 ± 10.9 kg, body fat 13.9 ± 4.6%, peak O2consumption: 48.0 ± 12.4 ml ⋅ kg−1⋅ min−1] exercised for 40 min (65% peak O2consumption) during water immersion at 39 or 18°C. Treincreased from 37.2 to 39.3°C ( P < 0.0001) after 40 min of exercise in 39°C water but was held constant to an increment of 0.5°C during exercise in 18°C water. Application of this thermal clamp reduced exercise-associated increments of plasma epinephrine (Epi) and norepinephrine (NE) by >50% ( P < 0.05) and abolished the postexercise increase in cortisol. Thermal clamping also reduced the exercise-induced leukocytosis and lymphocytosis. Multiple regression demonstrated that Trehad no direct association with lymphocyte subset mobilization but was significantly ( P < 0.0001) correlated with hormone levels. Epi was an important determinant of total leukocytes, lymphocytes, and CD3+, CD4+, CD8+, and CD3−CD16+/56+subset redistribution. The relationship between NE and lymphocyte subsets was weaker than that with Epi, with the exception of CD3−CD16+/56+counts, which were positively ( P < 0.0001) related to NE. Cortisol was negatively associated with leukocytes, CD14+monocytes, and CD19+B- and CD4+T-cell subsets but was positively related to granulocytes. We conclude that hyperthermia mediates exercise-induced immune cell redistribution to the extent that it causes sympathoadrenal activation, with alterations in circulating Epi, NE, and cortisol. |
| تدمد: | 1522-1601 8750-7587 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a0fa519196497fb6e79612e7ecf16d4Test https://doi.org/10.1152/jappl.1999.87.3.1178Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5a0fa519196497fb6e79612e7ecf16d4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15221601 87507587 |
|---|