Diastolic function is strongly and independently associated with cardiorespiratory fitness in central obesity
| العنوان: | Diastolic function is strongly and independently associated with cardiorespiratory fitness in central obesity |
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| المؤلفون: | Geraldine F. Clough, Magdalena Turzyniecka, Christopher D. Byrne, Andrew J. Krentz, Andrew J. Chipperfield, Sarah H. Wild |
| المصدر: | Journal of Applied Physiology. 108:1568-1574 |
| بيانات النشر: | American Physiological Society, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Adolescent, Physiology, Statistics as Topic, Physical fitness, Diastole, Physical exercise, Type 2 diabetes, Models, Biological, Ventricular Function, Left, Young Adult, Oxygen Consumption, Physiology (medical), Internal medicine, medicine, Humans, Computer Simulation, Obesity, Risk factor, business.industry, Cardiorespiratory fitness, medicine.disease, Endocrinology, Arterial stiffness, Cardiology, Female, business |
| الوصف: | Cardiorespiratory fitness [maximal O2 consumption (V̇o2max)] is an independent risk factor for type 2 diabetes; but in individuals at risk, factors influencing V̇o2max are poorly understood. We tested the hypothesis that V̇o2max is associated with diastolic function [subendocardial variability ratio (SEVR), %], as diastolic function influences myocardial perfusion. We studied 47 men and women with central obesity without diabetes. We measured fitness (V̇o2max) by treadmill testing and diastolic function (SEVR%) by pulse-wave analysis. We measured other factors influencing this relationship: insulin sensitivity [whole body glucose uptake-to-insulin concentration ratio (M/I)] by hyperinsulinemic euglycemic clamp, fatness by MR imaging and dual-energy X-ray absorptiometry, physical activity energy expenditure (metabolic equivalents of tasks) by the Sensewear Pro2 device, and muscle microvascular exchange capacity (capillary filtration coefficient) by venous plethysmography. Mean age of the subjects was 51 ± 9 (SD) yr. V̇o2max was associated with SEVR% ( r = 0.50, P = 0.001), fatness ( r = −0.39, P = 0.008), and HbA1c ( r = −0.35, P = 0.018), but not with whole body glucose uptake-to-insulin concentration ratio, metabolic equivalents of tasks, or capillary filtration coefficient. In regression modeling with age, sex, fatness, and SEVR% as explanatory variables, only age, sex, and SEVR% were independently associated with V̇o2max (SEVR% − standardized B coefficient = 0.37, 95% confidence interval = 0.003–0.18, P = 0.007). This model identified 46% of the variance in V̇o2max ( R2 = 0.46, P = 0.0001). There was a strong, independent association between V̇o2max and a measure of diastolic function in sedentary individuals with central obesity. |
| تدمد: | 1522-1601 8750-7587 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cdc30384032f8136d5d7aade13630d2Test https://doi.org/10.1152/japplphysiol.00023.2010Test |
| رقم الانضمام: | edsair.doi.dedup.....3cdc30384032f8136d5d7aade13630d2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15221601 87507587 |
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