Exercise reduces muscle glucose transport protein (GLUT-4) mRNA in type 1 diabetic patients
| العنوان: | Exercise reduces muscle glucose transport protein (GLUT-4) mRNA in type 1 diabetic patients |
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| المؤلفون: | Helena Vuorinen-Markkola, László Korányi, Veikko A. Koivisto, Raymond E. Bourey |
| المصدر: | Journal of Applied Physiology. 74:1755-1760 |
| بيانات النشر: | American Physiological Society, 1993. |
| سنة النشر: | 1993 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, medicine.medical_specialty, Hydrocortisone, Monosaccharide Transport Proteins, Physiology, medicine.medical_treatment, Muscle Proteins, 030209 endocrinology & metabolism, Physical exercise, 03 medical and health sciences, 0302 clinical medicine, Physiology (medical), Diabetes mellitus, Internal medicine, Humans, Insulin, Medicine, RNA, Messenger, Exercise, 030304 developmental biology, 2. Zero hunger, 0303 health sciences, Glucose Transporter Type 4, biology, business.industry, Glucose transporter, medicine.disease, Diabetes Mellitus, Type 1, Endocrinology, Basal (medicine), Growth Hormone, biology.protein, Hemoglobin, business, Body mass index, GLUT4 |
| الوصف: | We examined the effect of acute exercise on muscle glucose transporter (GLUT-4) protein and mRNA concentrations in nine male type 1 diabetic patients (age 31 +/- 3 yr, body mass index 23.6 +/- 0.7 kg/m2, insulin dose 44 +/- 4 U/day, glycosylated hemoglobin 7.8 +/- 0.4%) and in nine healthy control subjects (34 +/- 1 yr, 25.3 +/- 0.8 kg/m2). Three hours of cycle ergometer exercise was performed after an overnight fast. A needle biopsy (100–150 mg) was taken from the quadriceps femoris 40 min before and immediately after the end of exercise. During exercise, plasma glucose, insulin, cortisol, and growth hormone concentrations were higher in the diabetic patients than in the control subjects. In the basal state, GLUT-4 protein and mRNA concentrations were similar in the two groups. During exercise, GLUT-4 mRNA concentration decreased by 30–45% in the diabetic patients but remained unchanged in the control subjects. GLUT-4 protein content remained unchanged in both groups. These data suggest an abnormal GLUT-4 mRNA production or degradation or both in type 1 diabetic patients during physical exercise. |
| تدمد: | 1522-1601 8750-7587 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51225a41828b92b9e2e5598a4aaa838bTest https://doi.org/10.1152/jappl.1993.74.4.1755Test |
| رقم الانضمام: | edsair.doi.dedup.....51225a41828b92b9e2e5598a4aaa838b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15221601 87507587 |
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