Optimization of fermentation condition for antibiotic production by Xenorhabdus nematophila with response surface methodology
| العنوان: | Optimization of fermentation condition for antibiotic production by Xenorhabdus nematophila with response surface methodology |
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| المؤلفون: | Y.-H. Wang, Xiaoying Zhang, J.-T. Feng, Q. Zhang |
| المصدر: | Journal of Applied Microbiology. 104:735-744 |
| بيانات النشر: | Oxford University Press (OUP), 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Indoles, Central composite design, medicine.drug_class, Antibiotics, Applied Microbiology and Biotechnology, Xenorhabdus, Industrial Microbiology, Bioreactors, medicine, Benzopyrans, Response surface methodology, Food science, Bacteriological Techniques, Xenorhabdus nematophila, Chemistry, business.industry, General Medicine, Antibiotic production, Fermentation condition, Anti-Bacterial Agents, Biotechnology, Volume (thermodynamics), Fermentation, business |
| الوصف: | Aims: To evaluate the influence of environmental parameters on the production of antibiotics (xenocoumacins and nematophin) by Xenorhabdus nematophila and enhance the antibiotic activity. Methods and Results: Response surface methodology (RSM) was employed to study the effects of five parameters (the initial pH, medium volume in flask, rotary speed, temperature and inoculation volume) on the production of antibiotics in flask cultures by X. nematophila YL001. A 25−1-factorial central composite design was chosen to explain the combined effects of the five parameters and to design a minimum number of experiments. The experimental results and software-predicted values of production of antibiotics were comparable. The statistical analysis of the results showed that, in the range studied, medium volume in flask, rotary speed, temperature and inoculation volume had a significant effect (P |
| تدمد: | 1365-2672 1364-5072 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90e7829100f726844471d5a9eb07b27aTest https://doi.org/10.1111/j.1365-2672.2007.03599.xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....90e7829100f726844471d5a9eb07b27a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652672 13645072 |
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