유전자 조작기법을 통한 돼지 뇌종양 질환모델 개발의 필요성

التفاصيل البيبلوغرافية
العنوان:	유전자 조작기법을 통한 돼지 뇌종양 질환모델 개발의 필요성
المؤلفون:	Seon-Ung Hwang, Sang-Hwan Hyun
المصدر:	Journal of Animal Reproduction and Biotechnology, Vol 31, Iss 1, Pp 97-108 (2016)
بيانات النشر:	The Korean Society of Animal Reproduction and Biotechnology, 2016.
سنة النشر:	2016
المجموعة:	LCC:Biotechnology LCC:Medicine (General) LCC:Internal medicine
مصطلحات موضوعية:	porcine, scnt, disease-model animal, brain tumor, Biotechnology, TP248.13-248.65, Medicine (General), R5-920, Internal medicine, RC31-1245
الوصف:	Although many diseases could be treated by the development of modern medicine, there are some incurable diseases including brain cancer, Alzheimer disease, etc. To study human brain cancer, various animal models were reported. Among these animal models, mouse models are valuable tools for understanding brain cancer characteristics. In spite of many mouse brain cancer models, it has been difficult to find a new target molecule for the treatment of brain cancer. One of the reasons is absence of large animal model which makes conducting preclinical trials. In this article, we review a recent study of molecular characteristics of human brain cancer, their genetic mutation and comparative analysis of the mouse brain cancer model. Finally, we suggest the need for development of large animal models using somatic cell nuclear transfer in translational research.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English Korean
تدمد:	2671-4639 2671-4663
العلاقة:	http://www.e-jarb.org/journal/view.html?uid=2509&vmd=FullTest; https://doaj.org/toc/2671-4639Test; https://doaj.org/toc/2671-4663Test
DOI:	10.12750/JET.2016.31.1.97
الوصول الحر:	https://doaj.org/article/6a43035700c74840931ce553fd4b282aTest
رقم الانضمام:	edsdoj.6a43035700c74840931ce553fd4b282a
قاعدة البيانات:	Directory of Open Access Journals

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الوصف
تدمد:	26714639 26714663
DOI:	10.12750/JET.2016.31.1.97