Effects of sevoflurane increments on left ventricular systolic long-axis performance during sevoflurane-remifentanil anesthesia for cardiovascular surgery
التفاصيل البيبلوغرافية
العنوان:
Effects of sevoflurane increments on left ventricular systolic long-axis performance during sevoflurane-remifentanil anesthesia for cardiovascular surgery
The direct impact of sevoflurane on intraoperative left ventricular (LV) systolic performance during cardiac surgery has not been fully elucidated. Peak systolic tissue Doppler velocities of the lateral mitral annulus (S′) have been used to evaluate LV systolic long-axis performance. We hypothesized that incremental sevoflurane concentration (1.0–3.0 inspired-vol%) would dose-dependently reduce S′ in patients undergoing cardiac surgery due to mitral or aortic insufficiency. In 20 patients undergoing cardiac surgery in sevoflurane–remifentanil anesthesia, we analyzed intraoperative S′ values which were determined after 10 min exposure to sevoflurane at 1.0, 2.0, and 3.0 inspired-vol% (T1, T2, and T3, respectively) with a fixed remifentanil dose (1.0 μg/kg/min) using transesophageal echocardiography. Linear mixed-effect modeling demonstrated dose-dependent declines in S′ according to the end-tidal sevoflurane concentration increments (CET-sevoflurane, p
