Cerebrospinal Fluid Orexin Levels and Nocturnal Sleep Disruption in Alzheimer’s Disease Patients Showing Neuropsychiatric Symptoms
| العنوان: | Cerebrospinal Fluid Orexin Levels and Nocturnal Sleep Disruption in Alzheimer’s Disease Patients Showing Neuropsychiatric Symptoms |
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| المؤلفون: | Sergio Bernardini, Marzia Nuccetelli, Nicola Biagio Mercuri, Fabio Placidi, Claudio Liguori, Francesca Izzi |
| المصدر: | Journal of Alzheimer's Disease. 66:993-999 |
| بيانات النشر: | IOS Press, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, inorganic chemicals, medicine.medical_specialty, Alzheimer’s disease, neuropsychiatric symptoms, orexin, sleep, Aged, Aged, 80 and over, Alzheimer Disease, Biomarkers, Cognition, Female, Humans, Middle Aged, Orexins, Polysomnography, Sleep, Disease, 03 medical and health sciences, 0302 clinical medicine, Cerebrospinal fluid, Internal medicine, mental disorders, 80 and over, Medicine, Dementia, 030212 general & internal medicine, Cognitive decline, health care economics and organizations, medicine.diagnostic_test, business.industry, General Neuroscience, technology, industry, and agriculture, General Medicine, respiratory system, medicine.disease, Sleep in non-human animals, Orexin, Psychiatry and Mental health, Clinical Psychology, Endocrinology, Nocturnal sleep disruption, Settore MED/26 - Neurologia, Geriatrics and Gerontology, business, 030217 neurology & neurosurgery |
| الوصف: | Background: Alzheimer's disease (AD) is the most common form of dementia. It is characterized by a progressive deterioration of cognition, frequently associated with neuropsychiatric symptoms (NPS). Among NPS, sleep disturbances often affect AD patients. Orexinergic system dysregulation has been associated with sleep impairment in AD patients.Objective: The present study investigated CSF orexin levels in AD patients and their relationship with both NPS, measured by the neuropsychiatric inventory (NPI), and sleep, measured via polysomnography.Methods: This is a secondary analysis of a previous study investigating CSF biomarkers, sleep impairment and cognitive decline in AD patients. AD patients completing the NPI were included in this analysis and distributed in two groups based on the presence (NPI score >= 4, AD/NPS+) or absence (NPI score |
| تدمد: | 1875-8908 1387-2877 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a503ab59973efdcefbe6886ca59fdba8Test https://doi.org/10.3233/jad-180769Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....a503ab59973efdcefbe6886ca59fdba8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18758908 13872877 |
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