التفاصيل البيبلوغرافية
| العنوان: |
Efficacy of Acupuncture Treatment to Prevent Cerebral Vasospasm After Subarachnoid Hemorrhage: A Double-Blind, Randomized Placebo-Controlled Trial. |
| المؤلفون: |
Lee, Dong-Hyuk, Cho, Seung-Yeon, Yang, Seung-Bo, Lee, Hyoung-Min, Shin, Hee Sup, Lee, Seung Hwan, Koh, Jun Seok, Kwon, Seungwon, Jung, Woo-Sang, Moon, Sang-Kwan, Park, Jung-Mi, Ko, Chang-Nam, Kim, Ho, Park, Seong-Uk |
| المصدر: |
Journal of Alternative & Complementary Medicine; Dec2020, Vol. 26 Issue 12, p1182-1189, 8p |
| مصطلحات موضوعية: |
ACADEMIC medical centers, ACUPUNCTURE, ANALYSIS of covariance, CEREBRAL angiography, CEREBRAL infarction, CEREBRAL ischemia, CEREBRAL vasospasm, CHI-squared test, COMPARATIVE studies, ENDOTHELINS, INTRACRANIAL aneurysms, NEUROLOGIC manifestations of general diseases, NITRIC oxide, RESEARCH funding, STATISTICS, SUBARACHNOID hemorrhage, T-test (Statistics), TRANSCUTANEOUS electrical nerve stimulation, DATA analysis, RANDOMIZED controlled trials, TREATMENT effectiveness, BLIND experiment, DATA analysis software, DESCRIPTIVE statistics, MANN Whitney U Test, DISEASE complications, EVALUATION |
| مصطلحات جغرافية: |
SOUTH Korea |
| مستخلص: |
Objectives: To investigate the efficacy of acupuncture in preventing cerebral vasospasm following aneurysmal subarachnoid hemorrhage (SAH) and explore its underlying mechanism. Design: A randomized, double-blinded, and placebo-controlled trial. Setting/Location: Subjects were recruited from Kyung Hee University Hospital at Gangdong, Seoul, Korea Subjects: A total of 50 patients admitted with acute SAH. Interventions: The study group received acupuncture treatments (n = 25), while the control group underwent mock transcutaneous electrical nerve stimulation and sham acupuncture (n = 25) six times/week for 2 weeks. Outcome measures: The primary outcome was the incidence of delayed ischemic neurologic deficit (DIND), and secondary measurements included angiographic vasospasm, vasospasm-related infarction, modified Rankin Scale score, and plasma nitric oxide (NO) and endothelin-1 (ET-1) levels. Results: The study group treated with acupuncture showed a lower incidence of DIND (9.1%) than the control group (20.8%); however, this difference in the incidence of DIND was not statistically significant. The study group demonstrated better clinical outcomes, especially in functional recovery. Significant alterations in plasma NO and ET-1 levels after the 2-week intervention were observed only in the study group. Conclusions: Their study shows that acupuncture treatment improved functional recovery after SAH and could potentially prevent cerebral vasospasm. These effects could be attributed to the recovery of endothelial dysfunction by acupuncture through modulating the plasma NO and ET-1 levels. The study protocol has been registered on www.clinicaltrials.gov (NCT02275949). [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
